Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension

NCT ID: NCT07134621

Last Updated: 2025-09-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-16

Study Completion Date

2026-03-31

Brief Summary

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The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta. The main questions it aims to answer are:

* patients with exercise induced hypertension have signs of hypertensive heart disease?
* patients with exercise induced hypertension have increased arterial stiffness?
* patients with exercise induced hypertension have signs of hypertensive renal damage? Participants will be invited for an outpatient appointment during which medical history and physical investigation will be performed. They will undergo cardiopulmonary exercise testing during which blood pressure will be measured regularly. Transthoracic echocardiography will also be performed as well as assessment of arterial stiffness by measuring pulse wave velocity. Renal function will be assessed by blood and urine analysis.

Detailed Description

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Conditions

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Coarctation of the Aorta

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* adult patients aged 18 years and older
* history of coarctation of aorta repair

Exclusion Criteria

* haemodynamically significant recoarctation
* arterial hypertension at rest
* antihypertensive therapy
* associated haemodynamically significant valvular heart disease
* associated complex congenital heart disease
* advanced heart failure
* symptomatic arrhythmias
* cognitive or physical limitations to perform exercise stress testing
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Medical Centre Ljubljana

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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UMC Ljubljana

Ljubljana, , Slovenia

Site Status

Countries

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Slovenia

Other Identifiers

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0120-135/2023/6

Identifier Type: -

Identifier Source: org_study_id

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