Prospective Athlete's Heart Study

NCT ID: NCT05164328

Last Updated: 2021-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-23

Study Completion Date

2040-06-23

Brief Summary

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The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.

Detailed Description

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Conditions

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Athlete Heart

Keywords

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Athlete Atrial fibrillation Arrhythmias Cardiac remodelling Cardiomyopathy Genetics

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Athletes

1. Males and females aged 14-23 years old
2. Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:

1. Triathlon
2. Cycling
3. Distance running (≥ 1500 meters)
4. Rowing
5. Swimming

No intervention

Intervention Type OTHER

No intervention

Non-athletes

1. Males and females aged 14-23 years old
2. Non athletes engaged in \< 3 hours per week of physical activity

No intervention

Intervention Type OTHER

No intervention

Interventions

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No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Males and females aged 14-23 years old
2. Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:

1. Triathlon
2. Cycling
3. Distance running (≥ 1500 meters)
4. Rowing
5. Swimming
3. Non athletes engaged in \< 3 hours per week of physical activity

Exclusion Criteria

1. Medical history of cardiovascular disease
2. Current smoker of past history of smoking
3. Diabetes mellitus
Minimum Eligible Age

14 Years

Maximum Eligible Age

23 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Baker Heart and Diabetes Institute

OTHER

Sponsor Role collaborator

Victor Chang Cardiac Research Institute

UNKNOWN

Sponsor Role collaborator

University Hospital, Antwerp

OTHER

Sponsor Role collaborator

Jessa Hospital

OTHER

Sponsor Role collaborator

Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role lead

Responsible Party

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dr. Guido Claessen

Chair

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Guido Claessen, Prof. Dr.

Role: STUDY_CHAIR

UZ Leuven

Locations

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Baker Heart and Diabetes Institute

Melbourne, Victoria, Australia

Site Status RECRUITING

UZ Antwerpen

Edegem, Antwerp, Belgium

Site Status RECRUITING

Jessa Ziekenhuis Hasselt

Hasselt, Limburg, Belgium

Site Status RECRUITING

UZ Leuven

Leuven, Vlaams Brabants, Belgium

Site Status RECRUITING

Countries

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Australia Belgium

Central Contacts

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Guido Claessen, Prof. Dr.

Role: CONTACT

Email: [email protected]

Facility Contacts

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K Janssens

Role: primary

Andre La Gerche, Prof. Dr.

Role: backup

Hein Heidbuchel, Prof. Dr.

Role: primary

Caroline Van De Heyning, Prof. Dr.

Role: backup

Lieven Herbots, Dr.

Role: primary

Olivier Ghekiere, Dr.

Role: backup

Guido Claessen, Prof. Dr.

Role: primary

Rik Willems, Prof. Dr.

Role: backup

References

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De Bosscher R, Dausin C, Janssens K, Bogaert J, Elliott A, Ghekiere O, Van De Heyning CM, Sanders P, Kalman J, Fatkin D, Herbots L, Willems R, Heidbuchel H, La Gerche A, Claessen G; Pro@Heart Consortium. Rationale and design of the PROspective ATHletic Heart (Pro@Heart) study: long-term assessment of the determinants of cardiac remodelling and its clinical consequences in endurance athletes. BMJ Open Sport Exerc Med. 2022 Mar 18;8(1):e001309. doi: 10.1136/bmjsem-2022-001309. eCollection 2022.

Reference Type DERIVED
PMID: 35368514 (View on PubMed)

Related Links

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Other Identifiers

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57241

Identifier Type: -

Identifier Source: org_study_id