Neutrophil to Lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT ID: NCT07125352

Last Updated: 2025-08-15

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 190 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-05-20
• Study Completion Date: 2026-03-31

Brief Summary

Chronic obstructive pulmonary disease (COPD) stands as one of the leading causes of mortality worldwide. Acute exacerbations of COPD (AECOPD) lead to rapid respiratory function decline and worsened disease status. Despite recent studies, the ability of the neutrophil-to-lymphocyte ratio (NLR) to predict outcomes in patients with COPD remains controversial. It remains controversial whether NLR can predict clinical outcomes in hospitalized patients with AECOPD. Therefore, this study was conducted to investigate the predictive value of NLR for severity, adverse outcomes in hospitalized patients with AECOPD, and predicting treatment response in patients with AECOPD

Detailed Description

Chronic obstructive pulmonary disease (COPD) stands as one of the leading causes of mortality worldwide, posing an increasing economic burden. Acute exacerbations of COPD (AECOPD) are defined as acute deterioration of respiratory symptoms requiring additional treatment, leading to rapid respiratory function decline, diminished quality of life, and worsened disease status. Neutrophils are the most common type of white blood cells (WBC) and participate in multiple inflammatory and immune processes through phagocytosis and cytokine release. Lymphocytes play a crucial role as coordinators of the inflammatory and immune processes in various physiological mechanisms. The neutrophil-to-lymphocyte ratio (NLR) is calculated by dividing the number of neutrophils by the number of lymphocytes in the peripheral blood test, reflecting an increase in neutrophils and a secondary decrease in lymphocyte count during the inflammatory response. The NLR is considered a biological marker reflecting the inflammatory condition and is increasingly recognized in various disorders such as pneumonia, malignant, coronary artery disease, or hematological disorders.

Conditions

Chronic Obstructive Pulmonary Disease Exacerbation

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Interventions

neutrophil lymphocyte ratio in COPD patients

Neutrophil lymphocyte ratio in determining severity and prognosis in exacerbation of COPD patients

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients aged 18 and above, Patients who will be admitted at the Chest department, Ain-Shams University Hospitals, diagnosed with AECOPD based on the Global Initiative for Chronic Obstructive Lung Disease 2024 criteria

Exclusion Criteria

• Patients who refused treatment.
• COPD patients with Malignancy, hematological disorders

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ain Shams University

OTHER

Sponsor Role: lead

Responsible Party

hieba gamal ezz-elragal awad

Assistant professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Ain Shams University

Cairo, Abbasyea, Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Hieba G Ezzelregal, MD

Role: CONTACT

hiebagamal24@med.asu.edu.eg

01002041611

mona A alhady, MD

Role: CONTACT

Facility Contacts

Fatma S Ebeid

Role: primary

dr.fatm_ebeid@yahoo.com

01095569596

Other Identifiers

FMASU R123/2025

Identifier Type: -

Identifier Source: org_study_id