Biological Determinants of Sputum Rheology in Chronic Airway Diseases

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-09-15

Study Completion Date

2019-10-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The primary objective of this study is to investigate the biological determinants of sputum rheology variations.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smoking, COPD and Asthmatic Patients

NCT03187860

Pulmonary Disease, Chronic Obstructive Asthma Smoking

TERMINATED NA

Protocol Chronic Obstructive Pulmonary Disease

NCT00404430

Chronic Obstructive Pulmonary Disease Acute Respiratory Failure

COMPLETED

Assessment of Rheological Parameters of Human Sputum.

NCT02682290

COPD Asthma Cystic Fibrosis

COMPLETED NA

Dyspnea and Idiopathic Pulmonary Fibrosis

NCT04864990

Pulmonary Fibrosis

RECRUITING

Micro-environment Involvement in Muscle Alteration Induced

NCT04448626

Chronic Obstructive Pulmonary Disease Exacerbations Skeletal Muscle Atrophy

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Secondarily, this study aims to compare rheology parameters between different chronic airway disease sub-populations.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Asthma COPD Bronchiectasis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Asthma

The patients included in this group will have asthma, as specified in the inclusion criteria.

No interventions assigned to this group

COPD

The patients included in this group will have COPD, as specified in the inclusion criteria.

No interventions assigned to this group

Bronchiectasis

The patients included in this group will have bronchiectasis, as specified in the inclusion criteria.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Affiliate with or beneficiary of the French national single-payer health insurance system
* Patient capable of spontaneous mucus expectoration
* Consulting or hospitalized at the study centre

* Never- or former-smoker (\<10 pack-years)
* Medical history compatible with asthma
* Reversible post-brochodilator (or post-corticosteroid test) ventilatory obstruction (ratio of forced expiratory volume in 1 second : forced vital capacity \< 70%) or significant variation in respiratory function -- OR -- Bronchial hyperresponsiveness demonstrated during a broncho-provocation test

* Current- or former-smokers (\>10 pack years)
* Chronic obstructive pulmonary disease according to GOLD criteria

* Presence of bronchiectasis on computed tomography scan
* Cystic fibrosis has been ruled out

Exclusion Criteria

* Patient expresses opposition to the protocol
* Breast feeding or pregnant
* Metastatic neoplastic disease
* Other active pulmonary disease (tuberculosis, interstitial lung disease)
* Recent psychiatric disorder (in the past year and documented via a specialist consult)
* Consumption of illicit drugs or alcoholism
* Patients in an exclusion period determined by another study
* Patients under any type of legal guardianship
* Prisoners
* Impossible to correctly inform the patient
* Does not fluently read French
* Emergency situations

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No