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Effect of Ageing on Airway Remodeling

NCT ID: NCT01230879

Last Updated: 2021-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

101 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-15

Study Completion Date

2012-08-31

Brief Summary

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The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Detailed Description

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Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

Conditions

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Aging

Keywords

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Aging lung Airway remodeling Airway segmentation Chest CT

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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60 - 70 years old

EFR and TDM

Group Type EXPERIMENTAL

EFR and TDM

Intervention Type OTHER

EFR : Pulmonary function test TDM : tomodensitometry

71 - 80 years old

EFR and TDM

Group Type EXPERIMENTAL

EFR and TDM

Intervention Type OTHER

EFR : Pulmonary function test TDM : tomodensitometry

81 - 95 years old

EFR and TDM

Group Type EXPERIMENTAL

EFR and TDM

Intervention Type OTHER

EFR : Pulmonary function test TDM : tomodensitometry

Interventions

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EFR and TDM

EFR : Pulmonary function test TDM : tomodensitometry

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* People from 60 to 95 years old free from chest disease or history of chest disease

Exclusion Criteria

* Chronic cough
* Dyspnea
* Sinonasal or chest infection during enrollment
* Myocardial infarction.
* Current smoker or past smoker with more than 10 pack year intoxication
Minimum Eligible Age

60 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Montpellier

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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BOMMART Sebastien, MD

Role: PRINCIPAL_INVESTIGATOR

University Montpellier Hospital

Locations

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University Montpellier Hospital

Montpellier, , France

Site Status

Countries

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France

References

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Bommart S, Marin G, Bourdin A, Molinari N, Klein F, Hayot M, Vachier I, Chanez P, Mercier J, Vernhet-Kovacsik H. Relationship between CT air trapping criteria and lung function in small airway impairment quantification. BMC Pulm Med. 2014 Feb 28;14:29. doi: 10.1186/1471-2466-14-29.

Reference Type RESULT
PMID: 24581147 (View on PubMed)

Other Identifiers

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8268

Identifier Type: -

Identifier Source: org_study_id