MedDataX Logo

Aging of the Vascular Wall

NCT ID: NCT07122427

Last Updated: 2025-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-17

Study Completion Date

2026-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs. This decline in function increases the risk of numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases (CVD). CVD, the leading global cause of death, becomes more prevalent with age. Aging contributes to endothelial dysfunction, vessel stiffness, thickening, and impaired platelet function. These changes disrupt hemostatic processes and increase the risk of cardiovascular complications. Despite preventive strategies CVD remain a major public health challenge. Cellular aging, or senescence, affects all cell types, particularly endothelial cells and platelets. However, little research has compared the aging rates of different blood vessel types, such as arteries and veins. Given their distinct compositions and developmental origins, it is likely that their aging processes differ at molecular, cellular, and physiological levels.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Identification of Non Invasive Biomarkers of Immune Endothelial Injury and Repair Associated With Cardiac Allograft Vasculopathy

NCT01569334

Cardiac Allograft Vasculopathy
UNKNOWN NA

Geriatric Evaluation to Predict Mortality and Functional Recovery After Trans Aortic Valve Implantation

NCT02424370

Symptomatic Aortic Stenosis
COMPLETED

Coronary Artery Disease in Elderly People Referred for TAVI

NCT04930510

Aortic Stenosis Coronary Ang
UNKNOWN

Incidence and Management of Driveline Infection in Patients with CH-VAD

NCT06878456

Driveline Infection
COMPLETED

Retrospective Observational Study of Patients With a Sutureless Aortic Valve Implanted in the Cardiovascular and Thoracic Surgery Department of Dijon CHU

NCT03259945

Patients With a Sutureless Aortic Valve
COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Vascular Risk Aging Disorder

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Youngs

Patients aged 18 to 30 requiring coronary artery bypass grafting (CABG).

Graft collection

Intervention Type PROCEDURE

Sampling of superior venous and arterial grafts (internal mammary artery, great saphenous vein) after coronary artery bypass surgery.

Middle-aged

Patients aged 30 to 60 requiring coronary artery bypass grafting (CABG).

Graft collection

Intervention Type PROCEDURE

Sampling of superior venous and arterial grafts (internal mammary artery, great saphenous vein) after coronary artery bypass surgery.

Elderly

Patients aged 60 and more requiring coronary artery bypass grafting (CABG).

Graft collection

Intervention Type PROCEDURE

Sampling of superior venous and arterial grafts (internal mammary artery, great saphenous vein) after coronary artery bypass surgery.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Graft collection

Sampling of superior venous and arterial grafts (internal mammary artery, great saphenous vein) after coronary artery bypass surgery.

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Major patients requiring coronary artery bypass grafting (CABG).

Exclusion Criteria

* Hypertension, diabetes, systemic inflammatory disease.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Salvatore CAMPISI, MD

Role: PRINCIPAL_INVESTIGATOR

CHU SAINT-ETIENNE

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

CHU Saint-Etienne

Saint-Etienne, France, France

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Anne-Claire DUCHEZ, PhD

Role: CONTACT

[email protected]
(0)477421423 ext. +33

Salvatore CAMPISI, MD

Role: CONTACT

[email protected]
(0)477829058 ext. +33

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Anne-Claire DUCHEZ, PhD

Role: primary

[email protected]
(0)477421423 ext. +33

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

IRBN502025/CHUSTE

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Thrombosis and Its TrEatment With Anticoagulation
NCT02318342 RECRUITING NA
4 Cities for Assessing CAlcification PRognostic Impact After TAVI
NCT02935491 COMPLETED
The Effect of Transaortic Valve Replacement on the Endothelial Integrity and Function
NCT01993485 COMPLETED
China Senile Valvular Heart Disease Cohort Study
NCT02865798 UNKNOWN
Type II Diabetes Influence on Left Ventricular Remodeling and Outcomes in Patients Undergoing Aortic Valve Replacement Surgery.
NCT01862237 UNKNOWN NA
Study on Optimal Treatment Strategy for Elderly Patients With High-risk Complex Aortic Valve Disease
NCT05044377 UNKNOWN
Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation
NCT03135496 COMPLETED
Vascular Complications and Bleeding After Transfemoral TAVI
NCT03865043 COMPLETED
Real-World Prospective Parallel Controlled Study on Endovascular Therapy for Improving Perfusion and Remodeling of TBAD
NCT07022145 NOT_YET_RECRUITING
Endovascular Aortic Repair for Aortic Dissection
NCT01505309 UNKNOWN NA
Frailty of Elderly With Valvular Heart Disease and the Short Term Adverse Events
NCT05014750 UNKNOWN
Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling
NCT03411317 ACTIVE_NOT_RECRUITING
A Registry Study of Biomarkers in Heart Valve Disease
NCT06223906 RECRUITING
Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure
NCT06427304 RECRUITING
Image Fusion and Calcification Raising in Trans Aortic Valve Implantation
NCT03247465 WITHDRAWN NA
China Valve Registry Study-1
NCT02623907 UNKNOWN
Filling Pressures of the Left Ventricle in Patients With Significant Aortic Stenosis
NCT01727310 COMPLETED
Anatomical and Functional Assessment of Ex-vivo Coronary Perfusion
NCT05904678 UNKNOWN
EffecTAVI Registry
NCT05235555 RECRUITING
Prognostic Values of Coronary Microvascular Dysfunction Patients Treated with Rotational Atherectomy During Percutaneous Coronary Intervention
NCT06702748 ACTIVE_NOT_RECRUITING
A Preventive, Multidisciplinary Primary Care Intervention Organized Around a Therapeutic Garden: Acceptability to Patients Suffering from Cardio-neurovascular Pathology and to Those Involved in the Action.
NCT06646601 RECRUITING NA
Seniors Integrated Longitudinal cardioVascular Evaluation of Coronary Heart Disease: a Multicenter, Prospective Registry in China (SILVER-China)
NCT06880575 RECRUITING
Retinal Microvascular Network and Coronary Revascularization Surgery at the Dijon University Hospital
NCT05315349 COMPLETED NA
CGA-TAVI Registry to Evaluate the Predictive Value of a CGA in Predicting TAVI Outcomes
NCT01991444 COMPLETED
Effect of TF-TAVR on Emotional Status, Quality of Life, Frailty and Inflammation
NCT03308435 TERMINATED