Optimized Ablation of the Posterior Wall in Persistent Atrial Fibrillation
NCT ID: NCT07122336
Last Updated: 2025-08-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
384 participants
INTERVENTIONAL
2025-07-16
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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PVI group
PVI
PVI
PVI
PVI+ PWI group
PVI+ PWI
PVI
PVI
PWI
PWI
PVI+ PWI+EGM group
PVI+ PWI+EGM
PVI
PVI
PWI
PWI
EGM
EGM
Interventions
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PVI
PVI
PWI
PWI
EGM
EGM
Eligibility Criteria
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Inclusion Criteria
2. First-time ablation for persistent atrial fibrillation (PsAF)
3. Persistent AF definition: Sustained episodes lasting ≥7 days but ≤3 years (including episodes requiring pharmacologic or electrical cardioversion after ≥7 days)
4. Symptomatic AF with intolerance to at least one antiarrhythmic drug (AAD)
5. Documented PsAF episode: At least one recorded PsAF episode within the last 2 years prior to enrollment, confirmed by: ECG,Holter monitorin, Loop recorder, Telemetry, Transtelephonic monitoring (TTM),Implantable device
6. Ability and willingness to provide written informed consent
7. Compliance with all study follow-up requirements
Exclusion Criteria
2. Long-standing persistent AF: Continuous AF duration \>3 years
3. No prior attempt/pursuit of cardioversion or sinus rhythm maintenance
4. Contraindications to systemic anticoagulation
5. Pregnancy
6. Advanced renal or hepatic failure
7. Severe valvular heart disease or cyanotic congenital heart disease
8. Hypertrophic cardiomyopathy (HCM)
18 Years
80 Years
ALL
Yes
Sponsors
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Shanghai Chest Hospital
OTHER
Responsible Party
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Xu Liu
Doctor Liu
Locations
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Shanghai Chest Hospital
Shanghai, , China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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OAPWAF
Identifier Type: -
Identifier Source: org_study_id
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