Atrial Fibrillation Patients Treated With Catheter Ablation

NCT ID: NCT05266144

Last Updated: 2025-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-04

Study Completion Date

2025-12-31

Brief Summary

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This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.

Detailed Description

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The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.

Conditions

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Atrial Fibrillation Atrial Fibrillation Recurrent

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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atrial fibrillation

Atrial fibrillation patients who underwent radiofrequency ablation in Peking Union Medical College Hospital.

radiofrequency ablation

Intervention Type PROCEDURE

Bilateral pulmonary vein isolation, a kind of radiofrequency ablation, is performed in atrial fibrillation patients for atrial arrhythmia therapy.

Interventions

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radiofrequency ablation

Bilateral pulmonary vein isolation, a kind of radiofrequency ablation, is performed in atrial fibrillation patients for atrial arrhythmia therapy.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation
* 18-80 years old
* The anteroposterior diameter of the left atrium is less than 50mm via TTE
* Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists
* Patient consents to ablation treatment

Exclusion Criteria

* Intra-atrial thrombus detected by TEE
* Hyperthyroidism
* Previous radiofrequency ablation for atrial fibrillation
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Quan Fang, M.D.

Role: STUDY_CHAIR

Peking Union Medical College Hospital

Yongtai Liu, M.D.

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College Hospital

Locations

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Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yongtai Liu, M.D.

Role: CONTACT

+86-1069155068

Facility Contacts

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Yongtai Liu, M.D.

Role: primary

+86-1069155068

Quan Fang, M.D.

Role: backup

+86-1069155068

References

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Sun K, Qin X, Zhang D, Fang F, Wan R, Wang J, Yu J, Lai J, Yang D, Fan J, Cheng Z, Cheng K, Gao P, Zhang L, Deng H, Fang Q, Chen T, Liu Y. HFpEF correlated with better improvement of left atrial function in post-ablation patients with paroxysmal atrial fibrillation. Int J Cardiovasc Imaging. 2025 Apr;41(4):721-732. doi: 10.1007/s10554-025-03359-0. Epub 2025 Mar 1.

Reference Type DERIVED
PMID: 40025277 (View on PubMed)

Other Identifiers

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PUMCH-AF

Identifier Type: -

Identifier Source: org_study_id

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