Single-centre Descriptive Study of Taste in Frontotemporal Lobar Degeneration Through the Analysis of Taste Evoked Potentials
NCT ID: NCT07110207
Last Updated: 2025-08-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
NA
20 participants
INTERVENTIONAL
2025-08-18
2027-08-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Patients with FTLD often experience olfactory disorders (= sense of smell) and eating disorders: increased appetite, increased food intake and excessive consumption of sugary foods and snacking. This often leads to excessive weight gain. These eating disorders are still poorly understood at present.
In this context, we hypothesise that an alteration in the gustatory pathway - i.e. the way in which the brain perceives taste - could contribute to the eating disorders frequently observed in frontotemporal dementia (FTD), particularly in the marked attraction to sweet foods. We therefore wish to objectively evaluate the taste response to a sweet solution (sucrose) in patients with FTLD, using taste evoked potentials (TEPs). Taste evoked potentials are a reliable and reproducible technique for assessing brain activity in response to taste stimulation. One of their advantages is that they are non-invasive.
This study will document, for the first time in this disease, the characteristics of cortical (brain) processing of taste information.
The FRONTAL-PEG study is an interventional, regional, single-centre study conducted at the Dijon University Hospital, in collaboration with the CMRR (Memory, Resources and Research Centre) and the CSGA (Centre for Taste and Food Sciences).
All investigations are carried out at the CSGA (building adjacent to the Dijon University Hospital), with the exception of blood tests, which are carried out at the Dijon University Hospital.
The total duration of participation in the study is one morning. No follow-up is planned at the end of the study.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Prospective Monocentric Study of Taste in Patients With Minor or Major Cognitive Disorders Such as Alzheimer's, Through the Analysis of Gustatory Evoked Potentials.
NCT04860414
Dopaminergic Therapy for Frontotemporal Dementia Patients
NCT04937452
An Observational Study on Lecanemab Treatment for Early Alzheimer's Disease
NCT07153848
Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders
NCT03299062
Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's Disease
NCT03903211
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NA
SINGLE_GROUP
OTHER
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Patients with frontotemporal lobar degeneration
Blood test
Metabolic measurements and measurements of hormones related to food intake
Interrogation of the subject
Collection of socio-demographic data, medical and family history, medication
Cognitive assessment
MMSE and MoCA cognitive tests
Nutritional assessment
Anthropometric data (weight, height, BMI, waist circumference, hip circumference, android/gynoid ratio, triceps skinfold thickness, brachial circumference), bioelectrical impedance analysis (body fat percentage, lean body mass, body water percentage and bone mass in kg)
Taste tests
Recording of PEGs in response to a sucrose solution (prepared beforehand)
Sucrose taste detection test
Triangular test
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Blood test
Metabolic measurements and measurements of hormones related to food intake
Interrogation of the subject
Collection of socio-demographic data, medical and family history, medication
Cognitive assessment
MMSE and MoCA cognitive tests
Nutritional assessment
Anthropometric data (weight, height, BMI, waist circumference, hip circumference, android/gynoid ratio, triceps skinfold thickness, brachial circumference), bioelectrical impedance analysis (body fat percentage, lean body mass, body water percentage and bone mass in kg)
Taste tests
Recording of PEGs in response to a sucrose solution (prepared beforehand)
Sucrose taste detection test
Triangular test
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Person of legal age
* Fasting \> 2 hours before PEG measurement
* Body Mass Index (BMI) \< 30 kg/m² (according to medical record data)
* DLFT: diagnostic criteria for established or probable DLFT
Exclusion Criteria
* Persons subject to legal protection measures (guardianship, trusteeship)
* Persons subject to judicial protection measures
* Pregnant women, women in labour or breastfeeding women
* MMSE score \< 15 and/or MoCA score \< 10
* Known COVID-19 infection within 6 months prior to inclusion
* Active smokers (\> 4 cigarettes per day on a regular basis)
* Subject with a pacemaker (contraindication for bioelectrical impedance analysis)
* Subject with diabetes (type 1 or type 2)
* Taking medication (during the study) that interferes with taste
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Centre Hospitalier Universitaire Dijon
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
CHU Dijon Bourgogne
Dijon, , France
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
JACQUIN 2025
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.