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Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment

NCT ID: NCT00530478

Last Updated: 2007-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Brief Summary

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The purpose of this study is to demonstrate the efficacy and safety of donepezil on the recovery of cognitive function in patients with stroke and to delineate the neurophysiologic mechanisms of the therapeutic effect of donepezil on the recovery of cognitive network using functional neuroimaging technique.

Detailed Description

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Conditions

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Stroke

Keywords

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Donepezil Stroke Cognitive function Cognitive neural network

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Interventions

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Donepezil

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Ischemic stroke in the territory of right or left middle cerebral artery
* Post-onset duration of the recent-onset stroke is over 3 months
* Cognitive deficit ranged from 10 to 26 by minimal mental status examination (MMSE) score
* Disturbance in activities of daily living (ADL) ranged 0.5 \~ 2.0 by clinical dementia rating (CDR) scale

Exclusion Criteria

* Severe internal carotid artery stenosis on the lesion side
* Cardiac pacemaker or intracranial metal insertion
* Post-stroke seizure disorder or any evidence of epileptic spikes on electroencephalography (EEG)
Minimum Eligible Age

16 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Principal Investigators

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Suk Hoon Ohn, MD, MS

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

Yun Hee Park, MD

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

Locations

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Samsung Medical Center

Seoul, Seoul, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Yun-Hee Kim, MD, PHD

Role: CONTACT

Phone: 82-2-3410-2818

Email: [email protected]

Facility Contacts

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Yun-Hee Kim, MD, PHD

Role: primary

Other Identifiers

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2006-04-023

Identifier Type: -

Identifier Source: org_study_id