Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries

NCT ID: NCT07108751

Last Updated: 2025-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-01

Study Completion Date

2025-06-01

Brief Summary

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This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.

Detailed Description

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Gastroesophageal reflux disease (GERD) is a chronic condition characterized by reflux of stomach acid into the esophagus, with a prevalence reaching 20-30% in many populations. Beyond its gastrointestinal manifestations, GERD may have extraesophageal effects, including oral health disturbances such as dental erosion and caries. Exposure of the oral cavity to gastric acid, especially in patients with severe or nocturnal reflux, may contribute to enamel demineralization, increased tooth decay, and lower salivary pH.

Conditions

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Gastroesophageal Reflux Disease Severity Dental Caries

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Study group

Gastroesophageal reflux disease (GERD) patients.

Endoscopy

Intervention Type DEVICE

Endoscopy will be performed to all patient

Control group

Matched control group.

Endoscopy

Intervention Type DEVICE

Endoscopy will be performed to all patient

Interventions

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Endoscopy

Endoscopy will be performed to all patient

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age 18-65 years.
* Both sexes.
* Diagnosed with Gastroesophageal Reflux Disease (GERD) by endoscopy.
* Consent to participate.

Exclusion Criteria

* Xerostomia-related disorders.
* Recent antibiotics (last 4 weeks).
* Head/neck radiation history.
* Cognitive impairment affecting consent.
* Pregnant or lactating women.
* HbA1c above 6.4%.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tanta University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Abd El-Raouf Tawfik

Professor of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Tanta University

Tanta, El-Gharbia, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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36264PR1280/7/25

Identifier Type: -

Identifier Source: org_study_id

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