Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD)

NCT ID: NCT06457334

Last Updated: 2024-06-13

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-01-01
• Study Completion Date: 2025-01-01

Brief Summary

Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and symptoms improvement

Detailed Description

HeIicobacter PyIori (H.pyIori) is a gram-negative spiral shaped bacterium that affects up to 50% of the population worldwide, with a higher prevalences in the developing countries,Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder characterized by the regurgitation of gastric contents into the esophagus, resulting in a significant economic burden in direct and indirect costs and adversely affects the quality of life.GERD is caused by multiple different mechanisms that can be intrinsic, structural, or both, leading to the disruption of the esophago-gastric junction barrier resulting in exposure of the esophagus to acidic gastric contents, Clinically, GERD typically manifests with symptoms of heartburn and regurgitation. It can also present in an atypical fashion with extra-esophageal symptoms such as chest pain, dental erosions, chronic cough, laryngitis, or asthma.The relationship between H. pylori and gastroesophageal reflux disease (GERD) is still unclear, and the effect of H. pylori eradication on GERD treatment is unknown.Several studies have shown the inverse relationship between the occurrence of GERD and H.pyIori infection, in particular an increased severity of the disease is documented in patients with pre-existing symptoms .It has been showed that a markedly resolution of dyspepsia in patients at whom the eradication therapy was successful when compared with subjects with a persistent infection

Conditions

GERD

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• All patients diagnosed as GERD clinically and endscopically.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Sara Fergany Abdelhamid Elgamal

resident doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Saad Z Mahmoud, Professor

Role: STUDY_DIRECTOR

Assiut University

Locations

Alrajhi Hospital

Asyut, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Sara F Abdelhamid elgamal, master

Role: CONTACT

sarafergany139@gmail.com

+201023524835

Rasha M Omar, lecturer

Role: CONTACT

rasha.maree77@gmail.com

+201062821017

References

Ceylan A, Kirimi E, Tuncer O, Turkdogan K, Ariyuca S, Ceylan N. Prevalence of Helicobacter pylori in children and their family members in a district in Turkey. J Health Popul Nutr. 2007 Dec;25(4):422-7.

Reference Type: BACKGROUND

PMID: 18402185 (View on PubMed)

Other Identifiers

H.pylori eradication on GERD

Identifier Type: -

Identifier Source: org_study_id