Dental Erosion in Patients With Gastro-oesophageal Reflux
NCT ID: NCT02775149
Last Updated: 2020-11-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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SUSPENDED
30 participants
OBSERVATIONAL
2016-11-01
2021-12-31
Brief Summary
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A relationship between dental erosion and occurence of reflux disease was shown in numerous studies. On the one hand, patients with dental erosions frequently show reflux disease. On the other hand, many - but not all - reflux patients show dental erosions. It is believed that certain salivary parameters might explain, why not all reflux patients alike are affected of dental erosions.
The aim of this study is to analyze the relationship and the extent of occurrence of dental erosions and reflux symptoms, including investigation of certain salivary parameters.
Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Reflux patients
Patients who are treated at the Clinic for Gastroenterology and Gastrointestinal Oncology and have a 24-hours pH monitoring or impedance measurement performed for medical reasons
Collection of saliva samples
Collection of saliva samples
Visual detection of BEWE-index
Visual detection of BEWE-index
Interventions
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Collection of saliva samples
Collection of saliva samples
Visual detection of BEWE-index
Visual detection of BEWE-index
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Age \<18 years
* Intake of proton pump inhibitors (PPIs) if they are not discontinued at least one week before study participation
18 Years
ALL
No
Sponsors
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University of Göttingen
OTHER
Responsible Party
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Philipp Kanzow, Dr. med. dent., Dr. rer. medic.
Dr. med. dent.
Principal Investigators
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Annette Wiegand, Prof. Dr. med. dent.
Role: PRINCIPAL_INVESTIGATOR
Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany
References
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Bartlett D, Ganss C, Lussi A. Basic Erosive Wear Examination (BEWE): a new scoring system for scientific and clinical needs. Clin Oral Investig. 2008 Mar;12 Suppl 1(Suppl 1):S65-8. doi: 10.1007/s00784-007-0181-5. Epub 2008 Jan 29.
Hara AT, Zero DT. The potential of saliva in protecting against dental erosion. Monogr Oral Sci. 2014;25:197-205. doi: 10.1159/000360372. Epub 2014 Jun 26.
Moazzez R, Bartlett D, Anggiansah A. Dental erosion, gastro-oesophageal reflux disease and saliva: how are they related? J Dent. 2004 Aug;32(6):489-94. doi: 10.1016/j.jdent.2004.03.004.
Ranjitkar S, Smales RJ, Kaidonis JA. Oral manifestations of gastroesophageal reflux disease. J Gastroenterol Hepatol. 2012 Jan;27(1):21-7. doi: 10.1111/j.1440-1746.2011.06945.x.
Schlueter N, Ganss C, Potschke S, Klimek J, Hannig C. Enzyme activities in the oral fluids of patients suffering from bulimia: a controlled clinical trial. Caries Res. 2012;46(2):130-9. doi: 10.1159/000337105. Epub 2012 Apr 3.
Wang GR, Zhang H, Wang ZG, Jiang GS, Guo CH. Relationship between dental erosion and respiratory symptoms in patients with gastro-oesophageal reflux disease. J Dent. 2010 Nov;38(11):892-8. doi: 10.1016/j.jdent.2010.08.001. Epub 2010 Aug 7.
Wilder-Smith CH, Materna A, Martig L, Lussi A. Gastro-oesophageal reflux is common in oligosymptomatic patients with dental erosion: A pH-impedance and endoscopic study. United European Gastroenterol J. 2015 Apr;3(2):174-81. doi: 10.1177/2050640614550852.
Kanzow P, Wegehaupt FJ, Attin T, Wiegand A. Etiology and pathogenesis of dental erosion. Quintessence Int. 2016 Apr;47(4):275-8. doi: 10.3290/j.qi.a35625.
Other Identifiers
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2/11/15
Identifier Type: OTHER
Identifier Source: secondary_id
Erosion-Reflux
Identifier Type: -
Identifier Source: org_study_id