Non-invasive Diffusion-weighted Imaging With MRCP in the Diagnosis of Neoplastic Biliary Obstruction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-01

Study Completion Date

2025-12-01

Brief Summary

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This study aims to evaluate the diagnostic value of non-invasive diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting neoplastic biliary obstruction.

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Detailed Description

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Both surgeons and endoscopists value accurate approaches for identifying the source of biliary stricture in patients with obstructive jaundice. Cholangiocarcinoma or a benign stricture may cause a biliary stricture. Many imaging methods were used to diagnose the cause of biliary stricture.

Diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a non-invasive imaging modality that can potentially differentiate between malignant and benign biliary obstructions based on the measurement of water diffusion in tissues.

The gold standard of the research is endoscopic retrograde cholangiopancreatography (ERCP) and histology. Patients' diagnoses and follow-up were further verified by ERCP or histopathology.

Conditions

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Non-invasive Diffusion-weighted Imaging Magnetic Resonance Cholangiopancreatography Diagnosis Neoplastic Biliary Obstruction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Study group

Patients who are scheduled for magnetic resonance cholangiopancreatography and have undergone conventional imaging

Magnetic Resonance Cholangiopancreatography

Intervention Type OTHER

Patients who are scheduled for magnetic resonance cholangiopancreatography and have undergone conventional imaging

Interventions

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Magnetic Resonance Cholangiopancreatography

Patients who are scheduled for magnetic resonance cholangiopancreatography and have undergone conventional imaging

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult patients (≥18 years) with clinically suspected biliary obstruction (e.g., jaundice, elevated liver enzymes, cholestasis).
* Patients who are scheduled for magnetic resonance cholangiopancreatography (MRCP) and have undergone conventional imaging \[ultrasound or computed tomography (CT)\].
* Patients who will undergo further invasive procedures, e.g., endoscopic retrograde cholangiopancreatography (ERCP), biopsy.

Exclusion Criteria

* Patients with contraindications to magnetic resonance imaging (MRI) (e.g., pacemakers, metal implants).
* Patients who have previously undergone major biliary surgery or stent placement.
* Pregnant or lactating women.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No