Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography in Patients With Obstructive Jaundice

NCT ID: NCT06754397

Last Updated: 2024-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-31

Study Completion Date

2025-12-31

Brief Summary

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Evaluate the diagnostic accuracy of Magnetic Resonance Cholangiopancreatography (MRCP) compared with Ultrasound and Computed Tomography (CT) in patients with obstructive jaundice taking findings of ERCP/ PTC and histopathology as gold standard.

Detailed Description

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MRCP as a diagnostic role to determine the presence and severity of biliary and pancreatic ductal dilatation. It can also detect the length of the stricture as well as the exact cause and location of the obstructing lesion in comparison to other modalities.

Conditions

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Obstructive Jaundice

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients diagnosed with obstructive jaundice

MRCP as a role that is used as a non-invasive diagnostic tool for visualizing the pancreaticobiliary tree without the use of contrast media

Magnetic Resonance Cholangiopancreatography

Intervention Type DIAGNOSTIC_TEST

Three most important sequences included axial T2 weighted scan from liver to ampullary region followed by T2 weighted 3D FSE sequence acquired in coronal oblique plane using respiratory triggering by tying bellows over abdomen. After this breath hold HASTE sequence is acquired in coronal plane. Maximum intensity projection (MIP) and thick slab images are also used for interpretation. US, CECT and MRCP scans are interpreted by radiologists blinded to other imaging findings

Interventions

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Magnetic Resonance Cholangiopancreatography

Three most important sequences included axial T2 weighted scan from liver to ampullary region followed by T2 weighted 3D FSE sequence acquired in coronal oblique plane using respiratory triggering by tying bellows over abdomen. After this breath hold HASTE sequence is acquired in coronal plane. Maximum intensity projection (MIP) and thick slab images are also used for interpretation. US, CECT and MRCP scans are interpreted by radiologists blinded to other imaging findings

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Ultrasound Computed tomography

Eligibility Criteria

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Inclusion Criteria

Adult male and female patients clinically diagnosed obstructive jaundice are included in the study with positive laboratory tests.

Exclusion Criteria

Patients with non-obstructive (prehepatic/hepatic) cause of jaundice. Patients having contraindications to perform MRI (Patients with any electrically, magnetically or mechanically activated implants, pacemaker, cochlear implants or any metallic orthopedic implants and claustrophobic patients).
Minimum Eligible Age

15 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Demiana Mohsen Soliman

Radiological resident

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Magdy M Amin, Professor

Role: STUDY_DIRECTOR

Medical research ethics committee - Sohag university

Central Contacts

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Demiana M Soliman, Resident

Role: CONTACT

Phone: 01211992362

Email: [email protected]

Hisham A Amin, A. professor

Role: CONTACT

Phone: +20 115 115 2564

Other Identifiers

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Soh-Med--24-12-04MS

Identifier Type: -

Identifier Source: org_study_id