Effect of Static vs. Conversational AI-Generated Messages on Colorectal Cancer Screening Intent: a Randomized Controlled Trial
NCT ID: NCT07107152
Last Updated: 2025-08-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
915 participants
INTERVENTIONAL
2025-06-11
2025-06-21
Brief Summary
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Do personalized, AI-generated messages increase the self-reported likelihood of completing a stool-based CRC screening test within 12 months?
Do they also increase intent to undergo colonoscopy screening within 12 months?
Researchers will compare four groups: (1) no message control, (2) expert-written patient education materials, (3) a single AI-generated persuasive message, and (4) a motivational interviewing-style AI chatbot. These comparisons will help assess whether a conversational format offers added benefit over static AI or expert-generated content.
Participants will:
Be randomly assigned to one of the four study arms
Spend at least 3 minutes reading or interacting with their assigned material
Complete pre- and post-intervention surveys assessing intent to receive CRC screening
Receive messages tailored to their self-reported demographics, including age, political ideology, gender, education, community setting (urban, rural, suburb), self-reported health, and the last time they saw their PCP
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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AI Motivational Interviewing Chatbot
The motivational interviewing chatbot refers to a GPT-4.1 based chatbot that has been instructed to follow motivational interviewing principals to persuade participants to get screened for CRC.
AI Chatbot
Participants engage in a multi-turn conversation with a GPT-4.1 chatbot trained to emulate motivational interviewing techniques. The chatbot personalizes its conversation based on each participant's demographics (age, gender, political ideology, education, urbanicity, health status, and last PCP visit). Conversations last at least 3 minutes and aim to increase participant motivation to complete colorectal cancer screening.
single GPT generated message
The single GPT generated message is a single \~640 word persuasive message generated by GPT-4.1 where GPT-4.1 is provided with the same self-reported demographics.
single GPT generated message
Participants receive a single \~640-word message generated by GPT-4.1. The message is tailored to participants' self-reported demographics (age, gender, political ideology, education, urbanicity, health status, and last PCP visit). The message provides persuasive content encouraging colorectal cancer screening, emphasizing stool and colonoscopy screening options. Participants are required to read the message for a minimum of 3 minutes.
CRC JAMA patient page
The 642 word JAMA Patient Page contains up to date information on screening guidelines for CRC directed at patients.
Expert-Written Patient Materials
Participants read a 642-word expert-written educational summary from the Journal of the American Medical Association's Patient Page on colorectal cancer screening. The material is designed to provide objective information about screening options and guidelines recommended by the US Preventive Services Task Force. Participants are required to read the material for at least 3 minutes.
No Message
Participants read a \~640 word fictional short story about a cat and dog.
No interventions assigned to this group
Interventions
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single GPT generated message
Participants receive a single \~640-word message generated by GPT-4.1. The message is tailored to participants' self-reported demographics (age, gender, political ideology, education, urbanicity, health status, and last PCP visit). The message provides persuasive content encouraging colorectal cancer screening, emphasizing stool and colonoscopy screening options. Participants are required to read the message for a minimum of 3 minutes.
AI Chatbot
Participants engage in a multi-turn conversation with a GPT-4.1 chatbot trained to emulate motivational interviewing techniques. The chatbot personalizes its conversation based on each participant's demographics (age, gender, political ideology, education, urbanicity, health status, and last PCP visit). Conversations last at least 3 minutes and aim to increase participant motivation to complete colorectal cancer screening.
Expert-Written Patient Materials
Participants read a 642-word expert-written educational summary from the Journal of the American Medical Association's Patient Page on colorectal cancer screening. The material is designed to provide objective information about screening options and guidelines recommended by the US Preventive Services Task Force. Participants are required to read the material for at least 3 minutes.
Eligibility Criteria
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Inclusion Criteria
* Currently residing in the United States
* Self-reported no prior colorectal cancer screening (or unsure if screened)
* Able to read and understand English
* Consent to participate in a behavioral research study
Exclusion Criteria
* Failure to pass pre- or post-intervention attention checks
* Identified as non-human respondents by reCAPTCHA or other automated bot detection
* Completion time significantly shorter than the median, indicating inattentiveness
45 Years
75 Years
ALL
Yes
Sponsors
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University of Pennsylvania
OTHER
Responsible Party
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Locations
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Participants are recruited online via Prolific
Philadelphia, Pennsylvania, United States
Countries
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Other Identifiers
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crc_857299
Identifier Type: -
Identifier Source: org_study_id
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