Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia

NCT ID: NCT05810714

Last Updated: 2023-12-05

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

94 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-20

Study Completion Date

2022-02-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This clinical trial compares audio brochures and video brochures to usual care for increasing colorectal cancer (CRC) screening among adults living in Appalachia. Adults living in rural Appalachia experience increased rates of CRC, possibly due to the unique barriers to screening this population faces, such as lower socioeconomic status, limited health literacy, and less access to healthcare. The fecal immunochemical test (FIT) is a common CRC screening technique which allows individuals to complete the test at home and mail the kit back. A limitation of the current process for FIT screening outreach is that the instruction materials are heavy in text and not appropriate for individuals with limited health literacy. The audio and video brochures used in this clinical trial are instruction materials that have been specially designed to be appropriate for individuals of all health literacy levels. Providing these audio and video brochures with the FIT kits may increase CRC screening among adults living in Appalachia, compared to usual care.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

PRIMARY OBJECTIVE:

I. Conduct a pilot study of the two developed mail-based FIT outreach interventions versus (vs.) mailed usual care materials to establish acceptability and obtain preliminary efficacy data on increasing CRC screening.

OUTLINE: Participants are randomized to 1 of 3 arms.

ARM I: Participants receive the FIT kit and usual care on study.

ARM II: Participants receive the FIT kit with an audio brochure, disposable gloves and stool collection device, and scheduled reminder on study.

ARM III: Participants receive the FIT kit with a video brochure, disposable gloves and stool collection device, and scheduled reminder on study.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Colorectal Carcinoma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Arm I (FIT, usual care)

Participants receive the FIT kit and usual care on study.

Group Type ACTIVE_COMPARATOR

Best Practice

Intervention Type OTHER

Receive usual care

Fecal Immunochemical Test

Intervention Type OTHER

Receive FIT kit

Survey Administration

Intervention Type OTHER

Ancillary studies

Arm II (FIT, audio brochure, reminder)

Participants receive the FIT kit with an audio brochure, disposable gloves and stool collection device, and scheduled reminder on study.

Group Type EXPERIMENTAL

Fecal Immunochemical Test

Intervention Type OTHER

Receive FIT kit

Health Education

Intervention Type BEHAVIORAL

Receive audio brochure

Scheduled Notification

Intervention Type OTHER

Receive scheduled reminder

Survey Administration

Intervention Type OTHER

Ancillary studies

Arm III (FIT, video brochure, reminder)

Participants receive the FIT kit with a video brochure, disposable gloves and stool collection device, and scheduled reminder on study.

Group Type EXPERIMENTAL

Fecal Immunochemical Test

Intervention Type OTHER

Receive FIT kit

Health Education

Intervention Type BEHAVIORAL

Receive video brochure

Scheduled Notification

Intervention Type OTHER

Receive scheduled reminder

Survey Administration

Intervention Type OTHER

Ancillary studies

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Best Practice

Receive usual care

Intervention Type OTHER

Fecal Immunochemical Test

Receive FIT kit

Intervention Type OTHER

Health Education

Receive audio brochure

Intervention Type BEHAVIORAL

Health Education

Receive video brochure

Intervention Type BEHAVIORAL

Scheduled Notification

Receive scheduled reminder

Intervention Type OTHER

Survey Administration

Ancillary studies

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

standard of care standard therapy FIT iFOBT immunoassay fecal occult blood test immunochemical fecal occult blood test Immunochemical FOBT immunologic fecal occult blood test ScheduledNotification

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Mid-life men and women (50-64 years old)
* Live in Appalachia
* Had a medical visit in the past two years
* Are at average-risk for CRC (no history of CRC, polyps, inflammatory bowel disease, family history of CRC or hereditary CRC syndromes)
* Are not within CRC screening guidelines (no fecal occult blood test/FIT in the past year; flexible sigmoidoscopy in past five years; colonoscopy in past ten years)
Minimum Eligible Age

50 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Ohio State University Comprehensive Cancer Center

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Mira Katz

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Mira Katz, PhD, MPH

Role: PRINCIPAL_INVESTIGATOR

Ohio State University Comprehensive Cancer Center

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Katz ML, Shoben AB, Newell S, Hall C, Emerson B, Gray DM 2nd, Chakraborty S, Reiter PL. Video brochures in a mailed fecal immunochemical test outreach program provide cancer screening information in a user-friendly format for rural Appalachian community members. J Rural Health. 2024 Jan;40(1):96-103. doi: 10.1111/jrh.12772. Epub 2023 Jun 9.

Reference Type RESULT
PMID: 37296510 (View on PubMed)

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

NCI-2022-00144

Identifier Type: REGISTRY

Identifier Source: secondary_id

R21AG061496

Identifier Type: NIH

Identifier Source: secondary_id

View Link

OSU-21213

Identifier Type: -

Identifier Source: org_study_id