A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG
NCT ID: NCT07101367
Last Updated: 2025-08-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
PHASE1/PHASE2
60 participants
INTERVENTIONAL
2025-09-01
2026-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
QUADRUPLE
Study Groups
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Control
Control group receiving 10 ml of normal saline after induction of anesthesia then followed by infusion of normal saline till extubation in ICU
Normal saline
After induction of anesthesia give 10 ml of normal saline then followed by infusion of normal saline till extubation of patient in ICU
Dexmedetomidine
Starting with precedex loading dose after anesthesia induction then infusion till extubation in ICU
Dexmedetomidine
After induction of anesthesia give loading dose of precedex 1 mcg/kg diluted in 10 ml normal saline then attach syringe pump of precedex infusion of 0.5mcg/kg/hr till extubation in ICU
Methylprednisolone
To be diluted in 10 ml normal saline then given after induction of anesthesia then followed by normal saline infusion till extubation in ICU
Methylprednisolone
After induction of anesthesia give solumedrol of a dose 10mg/kg diluted in 10ml of normal saline followed by a normal saline infusion till the extubation of the patient in the ICU
Interventions
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Normal saline
After induction of anesthesia give 10 ml of normal saline then followed by infusion of normal saline till extubation of patient in ICU
Dexmedetomidine
After induction of anesthesia give loading dose of precedex 1 mcg/kg diluted in 10 ml normal saline then attach syringe pump of precedex infusion of 0.5mcg/kg/hr till extubation in ICU
Methylprednisolone
After induction of anesthesia give solumedrol of a dose 10mg/kg diluted in 10ml of normal saline followed by a normal saline infusion till the extubation of the patient in the ICU
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Sex: Both sexes.
3. American Society of Anaesthesiologists (ASA) Physical Status Class II, and III.
4. Scheduled for CABG on cardio-pulmonary bypass.
Exclusion Criteria
2. History of allergy to the medications used in the study.
3. Psychiatric disorders.
4. Significant cognitive dysfunction.
5. American Society of Anesthesiologists (ASA) Physical Status Class IV.
6. Chronic liver or kidney disease.
7. Poor systolic function ( Ejection fraction \< 40% ).
8. Pregnancy.
9. Redo CABG.
9.Infection during the week preceding surgery white blood cell count over 11,000 mm3 10.Pre-operative use of antibiotics or corticosteroids.
21 Years
60 Years
ALL
Yes
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Locations
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Ain Shams University
Cairo, Cairo Governorate, Egypt
Countries
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Central Contacts
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Other Identifiers
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FMASU MD219/2023
Identifier Type: -
Identifier Source: org_study_id
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