Eltrombopag Induced Liver Dysfunction During Treatment of Immunethrombocytopenic Purpura

NCT ID: NCT07093606

Last Updated: 2025-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-14

Study Completion Date

2026-01-20

Brief Summary

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this study amis to assess the incidence and severity of liver dysfunction in ITP patients receiving eltrombopag.

Detailed Description

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Conditions

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ITP - Immune Thrombocytopenia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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this group will receive Eltrombopag tabelts

ITP patients in this group receive Eltrombopag then follow up by liver functions test to evulate occurance of liver disorders .

Group Type EXPERIMENTAL

Eltrombopag

Intervention Type DRUG

ITP patients will receive Eltrombopag and evulate occurance of liver disordres .

Interventions

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Eltrombopag

ITP patients will receive Eltrombopag and evulate occurance of liver disordres .

Intervention Type DRUG

Eligibility Criteria

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Exclusion Criteria

Pre-existing liver disease (e.g., hepatitis, cirrhosis, NAFLD). Concurrent use of hepatotoxic drugs. Patients lost to follow-up.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Peter Adel Alfy

Resident , Internal medicine, Faculty of Medicine Sohag university

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sohag university hospital

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Peter A Alfy, Resident

Role: CONTACT

01274069691

Usama M Abdelaal, Professor

Role: CONTACT

01065962094

Facility Contacts

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Magdy M Amin, Professor

Role: primary

References

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Bidika E, Fayyaz H, Salib M, Memon AN, Gowda AS, Rallabhandi B, Cancarevic I. Romiplostim and Eltrombopag in Immune Thrombocytopenia as a Second-Line Treatment. Cureus. 2020 Aug 21;12(8):e9920. doi: 10.7759/cureus.9920.

Reference Type BACKGROUND
PMID: 32968581 (View on PubMed)

Kuter DJ. New thrombopoietic growth factors. Blood. 2007 Jun 1;109(11):4607-16. doi: 10.1182/blood-2006-10-019315. Epub 2007 Feb 8.

Reference Type BACKGROUND
PMID: 17289815 (View on PubMed)

Ptushkin VV, Vinogradova OY, Pankrashkina MM, Chernikov MV, Arshanskaya EG, Tkachenko NE. Thrombopoietin Receptor Agonists in the Treatment of Chronic Resistant Primary Immune Thrombocytopenia: Efficacy and Safety Data in Real Clinical Practice. Ter Arkh. 2018 Aug 17;90(7):70-76. doi: 10.26442/terarkh201890770-76.

Reference Type BACKGROUND
PMID: 30701925 (View on PubMed)

Other Identifiers

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Soh-Med--25-7-4MS

Identifier Type: -

Identifier Source: org_study_id

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