Obsessive-Compulsive Disorder: Insight, Trauma, and Links to Schizophrenia Spectrum Disorders
NCT ID: NCT07092826
Last Updated: 2025-08-11
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
ACTIVE_NOT_RECRUITING
Total Enrollment
300 participants
Study Classification
OBSERVATIONAL
Study Start Date
2023-02-01
Study Completion Date
2026-02-01
Brief Summary
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This study aims to better understand Obsessive-Compulsive Disorder (OCD) by examining the types and patterns of OCD symptom presentation. The investigators seek to determine how these symptoms impact overall daily functioning.
The study will also explore factors contributing to loss of insight in individuals with OCD, focusing on the potential roles of trauma, personality traits, and disorder severity. This may assist in identifying subgroups of patients who respond more favorably to treatment.
Additionally, the study will investigate how individuals with OCD and schizophrenia spectrum symptoms respond to combined sensory stimuli (e.g., auditory and tactile). The goal is to determine whether these responses are associated with specific brain processing patterns, trauma history, or characteristics of compulsive behavior. Insights from this research may help clarify why certain individuals develop repetitive behaviors such as checking and rituals.
Participants will be adults aged 18 to 65 diagnosed with OCD or schizophrenia spectrum disorders. Recruitment will occur through psychiatric clinics in Parma. Participation requires signed informed consent.
The study will also explore factors contributing to loss of insight in individuals with OCD, focusing on the potential roles of trauma, personality traits, and disorder severity. This may assist in identifying subgroups of patients who respond more favorably to treatment.
Additionally, the study will investigate how individuals with OCD and schizophrenia spectrum symptoms respond to combined sensory stimuli (e.g., auditory and tactile). The goal is to determine whether these responses are associated with specific brain processing patterns, trauma history, or characteristics of compulsive behavior. Insights from this research may help clarify why certain individuals develop repetitive behaviors such as checking and rituals.
Participants will be adults aged 18 to 65 diagnosed with OCD or schizophrenia spectrum disorders. Recruitment will occur through psychiatric clinics in Parma. Participation requires signed informed consent.
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Detailed Description
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Conditions
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Obsessive-Compulsive Disorder (OCD)
Schizophrenia and Schizophrenia Spectrum Psychosis
Study Design
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Observational Model Type
OTHER
Study Time Perspective
CROSS_SECTIONAL
Interventions
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Psychopathological assessment and non-invasive multisensory stimulation
This intervention consists of a non-invasive, cross-sectional assessment involving standardized psychopathological interviews and multisensory stimulation tasks (auditory, tactile, and combined). It is designed to explore formal and content-related features of obsessive-compulsive symptoms, insight levels, and trauma-related correlates in patients with OCD and schizophrenia spectrum disorders. No pharmacological treatment or experimental therapy is administered as part of this study.
Intervention Type
OTHER
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of Obsessive-Compulsive Disorder (OCD) and/or Schizophrenia Spectrum Disorder according to DSM-5 criteria (APA, 2013), as determined by a structured clinical interview (SCID-5-CV) (First et al., 2016).
* Age between 18 and 65 years.
* Participant agreement to take part in the study (informed consent).
* Age between 18 and 65 years.
* Participant agreement to take part in the study (informed consent).
Exclusion Criteria
* General medical condition that may be related to the psychiatric disorder.
* Alcohol or substance dependence or abuse.
* Cognitive impairment (score below 25 on the Mini Mental State Examination).
* Alcohol or substance dependence or abuse.
* Cognitive impairment (score below 25 on the Mini Mental State Examination).
Minimum Eligible Age
18 Years
Maximum Eligible Age
65 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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San Raffaele University Hospital, Italy
OTHER
Sponsor Role
collaborator
Matteo Tonna
OTHER
Sponsor Role
lead
Responsible Party
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Matteo Tonna
Associate Professor of Psychiatry, University of Parma
Responsibility Role
SPONSOR_INVESTIGATOR
Locations
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University of Parma
Parma, Emilia-Romagna, Italy
Site Status
Università degli Studi di Parma - Dipartimento di Medicina e Chirurgia
Parma, , Italy
Site Status
Countries
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Italy
References
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Provided Documents
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Document Type: Study Protocol
Document Type: Informed Consent Form: Informative Document
Document Type: Informed Consent Form: Informed Consent Form
Other Identifiers
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UNIPR-OCD-INSIGHT-290525-V1
Identifier Type: -
Identifier Source: org_study_id
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