Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy
NCT ID: NCT07086183
Last Updated: 2026-01-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
100 participants
OBSERVATIONAL
2026-12-01
2027-12-01
Brief Summary
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Aspirin is commonly used to prevent heart attacks and strokes, but it can also increase the risk of bleeding. Doctors often face a tough decision: should patients stop taking aspirin before surgery to reduce bleeding risk, or continue it to prevent blood clots?
To help answer this question, researchers will observe 100 patients, some who take aspirin regularly and some who don't, at hospitals in the U.S., Russia, and Italy. They will not change any treatments but will collect information about bleeding during surgery, blood test results, and CT scans after surgery.
The goal is to better understand the risks of continuing aspirin and to help doctors make safer decisions for future patients.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Chronic aspirin
Patients on chronic aspirin
Observation
Observation of intraoperative and postoperative outcomes
No aspirin
Patients who are not on aspirin
Observation
Observation of intraoperative and postoperative outcomes
Interventions
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Observation
Observation of intraoperative and postoperative outcomes
Eligibility Criteria
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Inclusion Criteria
* Patients willing to participate and provide an informed consent
* Patients undergoing elective craniotomy for cerebral aneurysm clipping
* Patients on chronic low-dose (75-100 mg) aspirin daily (aspirin group) or not on aspirin therapy for at least 7 days (control group) preoperatively.
Exclusion Criteria
* Use of other antiplatelet or anticoagulant medications within 7 days prior to surgery
* Known bleeding disorders (e.g. hemophilia, thrombocytopenia)
* History of intracranial hemorrhage unrelated to aneurysm
* Inability to provide informed consent
18 Years
ALL
No
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Shaun Gruenbaum
Principal Investigator
Locations
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Mayo Clinic Florida
Jacksonville, Florida, United States
Sapienza University of Rome
Roma, , Italy
Burdenko National Medical Research Center of Neurosurgery
Moscow, , Russia
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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25-006605
Identifier Type: -
Identifier Source: org_study_id
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