The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass

NCT ID: NCT01268917

Last Updated: 2010-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-03-31

Brief Summary

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Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there is little study about the effect of continuing aspirin until the surgery day on graft patency.So we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.

Detailed Description

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Conditions

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Coronary Artery Disease Off-pump Coronary Artery Bypass Aspirin

Keywords

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coronary artery disease off-pump coronary artery bypass aspirin

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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preoperative aspirin use

Group Type EXPERIMENTAL

aspirin

Intervention Type DRUG

aspirin 100mg daily until the surgery day

preoperative aspirin nonuse

Group Type NO_INTERVENTION

aspirin

Intervention Type DRUG

aspirin is stopped 5-7 days before operation

Interventions

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aspirin

aspirin 100mg daily until the surgery day

Intervention Type DRUG

aspirin

aspirin is stopped 5-7 days before operation

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing elective, off-pump coronary artery bypass with at least two grafts
* patient able to give informed consent

Exclusion Criteria

* on-pump CABG
* combined with the valve surgery
* Preoperative use of clopidogrel and warfarin
* allergy to aspirin
* History of severe liver disease
* History of bleeding diathesis,significant GI bleed
* Patient has known renal failure or contraindication for Cardiac CT Angio
* Redo CABG
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chinese Academy of Medical Sciences, Fuwai Hospital

OTHER

Sponsor Role lead

Responsible Party

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Fuwai Hospital

Locations

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Fuwai Hospital

Beijing, , China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Hengchao Wu, MD

Role: primary

References

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Chen S, Wu H, Yang T, Li B, Hu Y, Sun H. Does Early Graft Patency Benefit from Perioperative Statin Therapy? A Propensity Score-Matched Study of Patients Undergoing Off-Pump Coronary Artery Bypass Surgery. Cardiovasc Ther. 2019 Aug 6;2019:1582183. doi: 10.1155/2019/1582183. eCollection 2019.

Reference Type DERIVED
PMID: 31772605 (View on PubMed)

Other Identifiers

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Fuwai Hospital 2010-259

Identifier Type: -

Identifier Source: org_study_id