Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery
NCT ID: NCT02209909
Last Updated: 2016-04-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
48 participants
INTERVENTIONAL
2014-07-31
2015-09-30
Brief Summary
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Detailed Description
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Platelet activation can be evaluated by measuring platelet p-selectin using flowcytometry. In this study, we will compare platelet-activated markers and conventional coagulation tests.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DOUBLE
Study Groups
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aspirin continuation
Intervention : Low-dose aspirin (\< 100mg/day) is used before OPCAB surgery in the aspirin continuation group.
aspirin continuation
Patients are randomized to continue aspirin before OPCAB surgery.
aspirin discontinuation
Intervention: Low-dose aspirin is stopped more than 4 days before OPCAB surgery in the aspirin discontinuation group.
aspirin discontinuation
Patients are randomized to discontinue aspirin more than 4 days before OPCAB surgery.
Interventions
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aspirin continuation
Patients are randomized to continue aspirin before OPCAB surgery.
aspirin discontinuation
Patients are randomized to discontinue aspirin more than 4 days before OPCAB surgery.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* elective OPCAB
* informed consent
Exclusion Criteria
* emergency operation, re-operation
* co-existing valvular disease
* less than 6 months after cerebral vascular accident
* heparin induced thrombocytopenia
* heparin resistance
* menstrual phase
* preoperative cardiopulmonary bypass, continuous veno-veno hemofiltration, intra-aortic balloon pump application
* less than 12 months after myocardiac infarction
* less than 10 days after unstable angina
* less than 30 days after percutaneous coronary intervention
* less than 6 wks after bare metal stent insertion
* less than 12 months after drug eluting stent insertion
20 Years
80 Years
ALL
No
Sponsors
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Seoul National University Hospital
OTHER
Responsible Party
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Principal Investigators
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Yunseok Jeon, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Seoul National University Hospital
Locations
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Seoul National University Hospital
Seoul, , South Korea
Countries
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Other Identifiers
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OPCAB_ASA_PLT activation
Identifier Type: -
Identifier Source: org_study_id
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