Radiomic Analysis in OCT Imaging of Acquired Vitelliform Lesions.
NCT ID: NCT07074041
Last Updated: 2025-09-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
50 participants
OBSERVATIONAL
2022-03-01
2025-01-31
Brief Summary
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VLs are characterised by dynamic changes with progressive resorption of material and are associated with the appearance of visual symptoms, such as reduced visual acuity. The appearance of symptoms and changes in the characteristics of the VLs on retinal imaging are the basis of a sophisticated differential diagnosis, especially to distinguish a neovascular from a non-vascular sub-type.
To date, additional retinal imaging techniques can be helpful in performing differential diagnosis in unclear cases. Radiomics is a quantitative approach to medical imaging that can extract many features to improve medical diagnosis and assess response to treatment.
The aim of this study is to evaluate the performance of radiomics in the diagnosis of dynamic changes in VLs.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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study group
The study population includes patients diagnosed with acquired vitelliforms lesions (aVLs), defined by hyperautofluorescent material on fundus autofluorescence (FAF) and hyperreflective subretinal material on structural optical coherence tomography (OCT).
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* axial length higher than 26 mm
* the presence of clinically significant cataract
* the presence of significant concomitant ocular or systemic diseases (such as diabetic retinopathy, uveitis, glaucoma)
* known retinal disorders that could cause vitelliform lesions or retinal fluid (AMD, neovascularization, tractional pathologies, toxic or paraneoplastic syndromes)
* inherited dystrophies
18 Years
ALL
No
Sponsors
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Federico II University
OTHER
Responsible Party
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Gilda Cennamo
MD
Locations
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University of Naples, Federico II
Napoli, , Italy
Countries
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Other Identifiers
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05809856 Federico II
Identifier Type: -
Identifier Source: org_study_id
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