Robotic -Assisted Rehabilitation for Multiple Sclerosis: An Adaptive Approach for Individualized Therapy

NCT ID: NCT07070388

Last Updated: 2025-07-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 9 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-01-01
• Study Completion Date: 2025-06-27

Brief Summary

Therefore, the purpose of this study was to evaluate four-weeks of an upper limb robotic intervention for persons with Multiple Sclerosis. Participants completed a resistive and adaptive robotic training intervention whereby participants trained three times weekly for four consecutive weeks.

Detailed Description

Nine individuals with Multiple Sclerosis participated and were placed into two groups based that either trained their self-reported less affected limb (indirect training group; N=4) or trained their self-reported more affected limb (direct training group; N=5).

Conditions

Multiple Sclerosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Indirect training group

trained their self-reported less affected upper limb

Group Type: EXPERIMENTAL

end-effector robotic training

Intervention Type: DEVICE

For the robotic training sessions, a haptic wrist robot known as the Wristbot was used (ReWing, Genova, Italy). The training protocol consisted of an eccentric contraction-based exercise. Participants trained 3x per week for 4 consecutive weeks for approximately 25-mins per session.

Direct training group

trained their self-reported most affected limb

Group Type: EXPERIMENTAL

end-effector robotic training

Intervention Type: DEVICE

For the robotic training sessions, a haptic wrist robot known as the Wristbot was used (ReWing, Genova, Italy). The training protocol consisted of an eccentric contraction-based exercise. Participants trained 3x per week for 4 consecutive weeks for approximately 25-mins per session.

Interventions

end-effector robotic training

For the robotic training sessions, a haptic wrist robot known as the Wristbot was used (ReWing, Genova, Italy). The training protocol consisted of an eccentric contraction-based exercise. Participants trained 3x per week for 4 consecutive weeks for approximately 25-mins per session.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Diagnosis of MS
• No other neurological diagnosis
• No injury to the upper limb (i.e., broken bones)

Exclusion Criteria

• Relapse in the past 6 months

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Michael Holmes

OTHER

Sponsor Role: lead

Responsible Party

Michael Holmes

Associate Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Brock University

St. Catharines, Ontario, Canada

Countries

Canada

References

Mannella, K., Albanese, G. A., Ditor, D., Zenzeri, J. & Holmes, M. W. R. Preliminary Evaluation of an Adaptive Robotic Training Program of the Wrist for Persons with Multiple Sclerosis. Appl. Sci. 11, 9239 (2021).

Reference Type: BACKGROUND

Other Identifiers

Brock University

Identifier Type: -

Identifier Source: org_study_id