To Study the Mortality Outcome of Controlled Blood Pressure Participants

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-01

Study Completion Date

2027-02-01

Brief Summary

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Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials.

To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

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Detailed Description

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Sensitivity Analyses Excluding high risk of bias studies

Excluding short follow-up (\<1 year)

Conditions

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Valid MeSH Conditions Hypertension (HTN)

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Antihypertensive treatment

Participants assigned to interventions (pharmacological, device-based, or lifestyle) directed at lowering blood pressure or Antihypertensive agents, Blood pressure-lowering treatment, Antihypertensive therapy.

Antihypertensive treatment

Intervention Type DRUG

Any intervention (pharmacological, device-based, lifestyle) intentionally directed at lowering BP

Control groups receiving placebo, standard of care, or no intervention

Control/Comparator

Participants receiving placebo, standard of care, or no intervention

No interventions assigned to this group

Interventions

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Antihypertensive treatment

Any intervention (pharmacological, device-based, lifestyle) intentionally directed at lowering BP

Control groups receiving placebo, standard of care, or no intervention

Intervention Type DRUG

Other Intervention Names

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device-based blood pressure lowering lifestyle modification

Eligibility Criteria

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Inclusion Criteria

* Adults ≥18 years with diagnosed hypertension

Blood pressure controlled at target values defined by the study (e.g., \<140/90 mmHg or \<130/80 mmHg)

Any comorbidity allowed unless the study focuses on pregnancy or pediatric population

Exclusion Criteria

* Observational or retrospective studies

Pediatric or pregnant participants

Case reports, editorials, or conference abstracts without full data

Studies not reporting mortality outcomes separately for controlled BP

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No