Different Antihypertensive Drugs on Aortic Diseases

NCT ID: NCT06626607

Last Updated: 2024-10-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

704 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2024-09-30

Brief Summary

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The goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. The main question it aims to answer is:

Does different hypotensive drugs influence the prognosis of postoperative aortic patients? As participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.

Detailed Description

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This study is a cohort study that aims to explore the effects of different antihypertensive regimens on aortic remodelling in patients after aortic surgery by collecting the hospitalization and outpatient follow-up data. The study plans to gather perioperative and postoperative follow-up data from over 600 patients who underwent aortic surgery at the Eighth Affiliated Hospital and Beijing Anzhen Cardiothoracic Surgery Center. Patients were assigned based on the postoperative antihypertensive medication regimens. Datas was collected to compare the cardiovascular-related prognoses.

This study primarily includes patients who take oral antihypertensive medications after aortic surgery. The main observations will focus on postoperative complications related to the aorta (such as death, reoperation, dilation, etc.) and aortic diameters after the administration of different antihypertensive medications. Multivariate regression analysis will be employed to investigate the impact of different antihypertensive regimens on patients after aortic surgery.

Conditions

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Aortic Aneurysm Aortic Dissection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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CCB group

Patients' postoperative antihypertensive includes CCB (Calcium Calcium Entry Blockers)

CCB use

Intervention Type DRUG

Postoperative antihypertensive medication includes CCB

non-CCB group

Patients' postoperative antihypertensive does not include CCB

non-CCB use

Intervention Type DRUG

Postoperative antihypertensive medication does not include CCB

Interventions

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CCB use

Postoperative antihypertensive medication includes CCB

Intervention Type DRUG

non-CCB use

Postoperative antihypertensive medication does not include CCB

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* aortic diseases\' patients underwent aortic surgery who require antihypertensive medication.

Exclusion Criteria

* Patients with active vasculitis;
* Patients allergic to contrast agent
* Patients with aorta variation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Anzhen Hospital

OTHER

Sponsor Role collaborator

Eighth Affiliated Hospital, Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Zhang Tingting

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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ZB-KYIRB-AF/SC-08/02.0

Identifier Type: -

Identifier Source: org_study_id

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