Resistant Arterial Hypertension Cohort Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

74 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-04-30

Study Completion Date

2017-05-31

Brief Summary

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The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.

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Detailed Description

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Conditions

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Hypertension Essential Hypertension Resistant Hypertension

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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chlorthalidone

Intervention Type DRUG

chlorthalidone 25mg/d vs. chlorthalidone 50mg/d

motivational invervention

motivational interview(s) vs. repeated calls vs. no particular intervention

motivational intervention for non-compliant individuals

Intervention Type BEHAVIORAL

motivational interview(s) vs. repeated calls vs. no particular intervention

standardized anti-hypertensive treatment

Intervention Type DRUG

olmesartan, amlodipine, chlorthalidone, +- spironolactone

Interventions

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chlorthalidone

chlorthalidone 25mg/d vs. chlorthalidone 50mg/d

Intervention Type DRUG

motivational intervention for non-compliant individuals

motivational interview(s) vs. repeated calls vs. no particular intervention

Intervention Type BEHAVIORAL

standardized anti-hypertensive treatment

olmesartan, amlodipine, chlorthalidone, +- spironolactone

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* informed consent
* resistant hypertension at the moment of inclusion
* 18 years or more, both sexes are included
* women at reproductive age: consenting to use oral contraception

Exclusion Criteria

* patients mentally impaired or unable to give informed consent
* patients speaking only a foreign language other than French, German, or English
* patients living far away, making the study visits not practical

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No