Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients
NCT ID: NCT07063563
Last Updated: 2025-07-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
52 participants
INTERVENTIONAL
2025-07-23
2025-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SEQUENTIAL
TREATMENT
QUADRUPLE
Study Groups
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Normoxia
Sham air (ambient air) (5l/min) will be applied with the oxygen concentrator EverFlo TM via nasal cannula
ambiant air
Standard ambiant air will be breathed during endurance training. ambiant air
Hyperoxia
Standardized supplemental oxygen therapy (SSOT) at 5 L/min will be delivered using the EverFlo™ oxygen concentrator via nasal cannula during training.
Oxygen
SSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training
Hypoxia
This group will train at moderate altitude
ambiant air
Standard ambiant air will be breathed during endurance training. ambiant air
Interventions
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ambiant air
Standard ambiant air will be breathed during endurance training. ambiant air
Oxygen
SSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training
ambiant air
Standard ambiant air will be breathed during endurance training. ambiant air
Eligibility Criteria
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Inclusion Criteria
* Stable clinical condition for \>3 weeks (e.g., no exacerbations)
* Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
* Informed consent documented by signature
Exclusion Criteria
* Long-term oxygen therapy
* Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
* Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
* Women who are pregnant or breastfeeding
* Enrolment in another clinical trial involving active treatment
18 Years
ALL
No
Sponsors
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National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
OTHER_GOV
University of Zurich
OTHER
Eastern Switzerland University of Applied Sciences
OTHER
Responsible Party
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Locations
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National center for cardiology and internal medicine
Bishkek, Kyrgyzstan, Kyrgyzstan
Eastern Switzerland University of Applied Sciences
Sankt Gallen, Canton of St. Gallen, Switzerland
Countries
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Central Contacts
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Facility Contacts
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Talant Sooronbaev, Prof.
Role: primary
Other Identifiers
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inRehaExO2_FOT
Identifier Type: -
Identifier Source: org_study_id
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