The Impact of Medication Adherence in Patients With Type 2 Diabetes and Disabilities

NCT ID: NCT07052708

Last Updated: 2025-07-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 365295 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-01-01
• Study Completion Date: 2023-09-30

Brief Summary

Individuals with disabilities and type 2 diabetes tend to have worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators evaluated the role of medication adherence. A retrospective, cohort study was conducted using data from the Korean National Health Insurance Service (K-NHIS) database.

Detailed Description

Type 2 diabetes mellitus (T2DM) is a well-established risk factor for cardiovascular disease (CVD). In recent years, self-care has become a central component of diabetes management, with growing emphasis on medication adherence, physical activity, and lifestyle modifications to reduce CVD risk and improve long-term outcomes. As a result, limited capacity for self-care has been increasingly recognized as a major contributor to health disparities.

Approximately 25% of individuals with disabilities have T2DM, and those with physical or mental impairments often face substantial barriers to effective self-management. These challenges-including limited mobility and reduced access to health information-can lead to poor glycemic control and heightened cardiovascular risk.

However, most prior studies have primarily focused on describing the elevated risk of CVD in individuals with disabilities. Whether suboptimal medication adherence mediates the association between disability and cardiovascular outcomes remains unclear.

Therefore, this study aims to compare medication adherence between patients with and without disabilities and to assess whether differences in adherence contribute to disparities in the incidence of CVD.

Conditions

Disabilities; Type 2 Diabetes

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Disability

Individuals were classified as having a disability if they were officially registered as of the index date. Physical disability included conditions such as limb impairment, brain lesion, visual or auditory impairment, speech impairment, facial disfigurement, and epilepsy. Mental disability included intellectual disability, autism spectrum disorder, and psychiatric disorders.

No adherence group

Intervention Type: BEHAVIORAL

Patients with poor adherence was defined as medication possession ratio(MPR) \<50%.

Adherence group

Intervention Type: BEHAVIORAL

Patients with good adherence was defined as medication possession ratio(MPR) ≥50%.

No disability

Individuals who were not officially registered with any physical or mental disability as of the index date.

No interventions assigned to this group

Interventions

No adherence group

Patients with poor adherence was defined as medication possession ratio(MPR) \<50%.

Intervention Type: BEHAVIORAL

Adherence group

Patients with good adherence was defined as medication possession ratio(MPR) ≥50%.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Patients who newly diagnosed T2DM between between January 1, 2010, and December 31, 2023

Exclusion Criteria

• individuals with a history of MI, stroke, percutaneous coronary intervention, peripheral arterial disease, chronic kidney disease, or cancer before the diagnosis of diabetes were excluded.
• individuals with who already had diabetics related complication

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Samsung Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Ki Hong Choi

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

MedicationAdherence_Disability

Identifier Type: -

Identifier Source: org_study_id