Explainable Machine Learning for Predicting Early Gastric Cancer

NCT ID: NCT07047937

Last Updated: 2025-07-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-28

Study Completion Date

2025-07-01

Brief Summary

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Abstract Background: Early detection of gastric cancer is crucial for improving patient survival rates. Currently, the primary method for diagnosing early-stage gastric cancer is endoscopy, which has various limitations. Additionally, single laboratory tests continue to fall short of the requirements for early screening. This study aims to develop a machine learning (ML) model using clinical data to predict early-stage gastric cancer and apply SHapley Additive exPlanation (SHAP) values to explain the ML model.

Methods: This study involved patients who provided gastric tissue samples at Wenzhou Central Hospital from 2019 to 2023. The investigators gathered various laboratory test results from these patients. The investigators constructed and evaluated nine ML models to predict early-stage gastric cancer, using the area under the curve (AUC), accuracy, and sensitivity to assess their performance. For the most effective prediction model, The investigators utilized the SHAP method to determine the features' importance and explain the ML model.

Detailed Description

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Conditions

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Early Gastric Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* all patients with a gastric tissue pathology result are included

Exclusion Criteria

* unclear or incomplete pathology results
* significant missing laboratory data
* progressive and advanced gastric cancer
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wenzhou Central Hospital

OTHER

Sponsor Role lead

Responsible Party

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sunmeng chen

Resident in gastrointestinal surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Wenzhou Central Hospital

Wenzhou, Zhejiang, China

Site Status

Countries

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China

Other Identifiers

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202506031607000064611

Identifier Type: -

Identifier Source: org_study_id

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