Development of Novel Gastric Cancer Screening and Diagnosis Technologies Using Tongue Imaging and Study of Tongue Image Changes Mechanisms
NCT ID: NCT06078930
Last Updated: 2025-06-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100000 participants
OBSERVATIONAL
2021-06-01
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Patients with gastric cancer
Tongue imaging, tougue coating, saliva, gastric juice, and feces
Tongue images, coating, saliva, gastric juice, and feces on the tongue and clinical data of patients with gastric cancer and healthy participants will be collected.
Healthy participants
Tongue imaging, tougue coating, saliva, gastric juice, and feces
Tongue images, coating, saliva, gastric juice, and feces on the tongue and clinical data of patients with gastric cancer and healthy participants will be collected.
Interventions
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Tongue imaging, tougue coating, saliva, gastric juice, and feces
Tongue images, coating, saliva, gastric juice, and feces on the tongue and clinical data of patients with gastric cancer and healthy participants will be collected.
Eligibility Criteria
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Inclusion Criteria
* Histologically or cytologically confirmed gastric cancer
* No prior chemotherapy, radiotherapy, biotherapy, immunotherapy or other anti-tumor treatment for gastric cancer
* Subject volunteers to join the study, Signs informed consent, has good compliance and can cooperate with follow-up
* 18≤age≤90
* Willingness to participate in the study, signing an informed consent form, and demonstrating good compliance
Exclusion Criteria
* Gastric cancer that has been treated by chemotherapy, radiotherapy, biotherapy, immunotherapy or other anti-tumor therapy
* The use of glucocorticoids and antibiotics in the past three months
* History of long-term medication
* Presence of oral diseases such as tooth and gum diseases
* Subjects who had other factors that might force them to terminate the research ahead of time, such as the development of other severe disease (including mental disease) that required combined treatment, seriously abnormal laboratory examination value, and family or social factors that might affect the subject safety or experimental data collection, as judged by the researchers
* History of malignant tumors
* The use of glucocorticoids and antibiotics in the past three months
* History of long-term medication
* Presence of oral diseases such as tooth and gum diseases
* Subjects who had other factors that might force them to terminate the research ahead of time, such as the development of other severe disease (including mental disease) that required combined treatment, seriously abnormal laboratory examination value, and family or social factors that might affect the subject safety or experimental data collection, as judged by the researchers
18 Years
90 Years
ALL
Yes
Sponsors
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Sichuan Cancer Hospital and Research Institute
OTHER
The First Affiliated Hospital of Zhejiang Chinese Medical University
OTHER
Wenzhou Medical University
OTHER
Fujian Cancer Hospital
OTHER_GOV
RenJi Hospital
OTHER
Tongde Hospital of Zhejiang
UNKNOWN
Kecheng District People's Hospital
UNKNOWN
Yueyang Central Hospital
OTHER
Shandong Cancer Hospital and Institute
OTHER
Shanxi Province Cancer Hospital
OTHER
Liaoning Cancer Hospital & Institute
OTHER
Harbin Cancer Hospital
UNKNOWN
Yuhang District People's Hospital
UNKNOWN
Hainan Cancer Hospital
OTHER
Zigong Fourth People's Hospital
UNKNOWN
Henan University of Science and Technology
OTHER
Shangyu People's Hospital of Shaoxing City
UNKNOWN
Red Cross Hospital, Hangzhou, China
OTHER
The Affiliated Hospital of Hangzhou Normal University
OTHER
Xiaoshan District First People's Hospital
UNKNOWN
Xianju County People's Hospital
UNKNOWN
Lin'an District First People's Hospital
UNKNOWN
First Affiliated Hospital of Wenzhou Medical University
OTHER
Wenzhou Central Hospital
OTHER
The Third Affiliated Hospital of Wenzhou Medical University
OTHER
Leqing City People's Hospital
UNKNOWN
The Affiliated Hospital of Medical School of Ningbo University
UNKNOWN
Cixi City People's Hospital
UNKNOWN
Mingzhou Hospital, Zhejiang University
UNKNOWN
Fourth Hospital of Ningbo City
UNKNOWN
Fenghua District People's Hospital
UNKNOWN
Fenghua Traditional Chinese Medicine Hospital, Ningbo City
UNKNOWN
Xikou Hospital, Fenghua District, Ningbo City
UNKNOWN
Chengdu University of Traditional Chinese Medicine
OTHER
Guang'an Hospital, Affiliated to Chengdu University of Traditional Chinese Medicine
UNKNOWN
Jiangsu Cancer Institute & Hospital
OTHER
Jiangsu Provincial People's Hospital
OTHER
The First People's Hospital of Changzhou
OTHER
The First Affiliated Hospital of Soochow University
OTHER
Jiangsu Provincial Hospital of Traditional Chinese Medicine
UNKNOWN
Zidong Campus of Jiangsu Provincial Hospital of TCM
UNKNOWN
Wuxi Traditional Chinese Medicine Hospital
UNKNOWN
First Affiliated Hospital of Harbin Medical University
OTHER
The First Affiliated Hospital of Anhui Medical University
OTHER
Peking University Cancer Hospital & Institute
OTHER
Xijing Hospital
OTHER
Guangdong Provincial Hospital of Traditional Chinese Medicine
OTHER
Xiangya Hospital of Central South University
OTHER
Yunnan Cancer Hospital
OTHER
Chongqing University Cancer Hospital
OTHER
Gansu Cancer Hospital
OTHER
Fudan University
OTHER
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
OTHER
First Affiliated Hospital of Guangxi Medical University
OTHER
Tianjin Medical University Cancer Institute and Hospital
OTHER
Huzhou Central Hospital
OTHER
Zhoushan Hospital, Zhejiang
UNKNOWN
Zhejiang Cancer Hospital
OTHER
Responsible Party
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Xiangdong Cheng
MD
Locations
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Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Countries
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Central Contacts
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Facility Contacts
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References
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Yuan L, Yang L, Zhang S, Xu Z, Qin J, Shi Y, Yu P, Wang Y, Bao Z, Xia Y, Sun J, He W, Chen T, Chen X, Hu C, Zhang Y, Dong C, Zhao P, Wang Y, Jiang N, Lv B, Xue Y, Jiao B, Gao H, Chai K, Li J, Wang H, Wang X, Guan X, Liu X, Zhao G, Zheng Z, Yan J, Yu H, Chen L, Ye Z, You H, Bao Y, Cheng X, Zhao P, Wang L, Zeng W, Tian Y, Chen M, You Y, Yuan G, Ruan H, Gao X, Xu J, Xu H, Du L, Zhang S, Fu H, Cheng X. Development of a tongue image-based machine learning tool for the diagnosis of gastric cancer: a prospective multicentre clinical cohort study. EClinicalMedicine. 2023 Feb 6;57:101834. doi: 10.1016/j.eclinm.2023.101834. eCollection 2023 Mar.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
Wang FH, Zhang XT, Li YF, Tang L, Qu XJ, Ying JE, Zhang J, Sun LY, Lin RB, Qiu H, Wang C, Qiu MZ, Cai MY, Wu Q, Liu H, Guan WL, Zhou AP, Zhang YJ, Liu TS, Bi F, Yuan XL, Rao SX, Xin Y, Sheng WQ, Xu HM, Li GX, Ji JF, Zhou ZW, Liang H, Zhang YQ, Jin J, Shen L, Li J, Xu RH. The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021. Cancer Commun (Lond). 2021 Aug;41(8):747-795. doi: 10.1002/cac2.12193. Epub 2021 Jul 1.
Li MY, Zhu DJ, Xu W, Lin YJ, Yung KL, Ip AWH. Application of U-Net with Global Convolution Network Module in Computer-Aided Tongue Diagnosis. J Healthc Eng. 2021 Nov 18;2021:5853128. doi: 10.1155/2021/5853128. eCollection 2021.
Other Identifiers
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IRB-2021-289
Identifier Type: -
Identifier Source: org_study_id
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