Development and Validation of a Deep Learning System for Nasopharyngeal Carcinoma Using Endoscopic Images

NCT ID: NCT05627310

Last Updated: 2022-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-01

Study Completion Date

2024-03-31

Brief Summary

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Develop a deep learning algorithm via nasal endoscopic images from eight NPC treatment centerto detect and screen nasopharyngeal carcinoma(NPC).

Detailed Description

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Nasopharyngeal carcinoma (NPC) is an epithelial cancer derived from nasopharyngeal mucosa. Nasal endoscopy is the conventional examination for NPC screening. It is a major challenge for inexperienced endoscopists to accurately distinguish NPC and other benign dieseases. In this study, we collcet multi-center endoscopic images and train a deep learning model to detect NPC and indicate tumor location. Then, the model perfomance will be compared with endoscopists and be tested prospectively with external dataset.

Conditions

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Nasopharyngeal Carcinoma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Training Cohort

Nasopharyngeal endoscopic images collected from 8 hospitals all over China

No interventions assigned to this group

Validation Cohort

Nasopharyngeal endoscopic images collected from 8 hospitals all over China

Diagnostic

Intervention Type OTHER

Training dataset was used to train the deep learning model, which was validated and tested by external dataset.

Testing Cohort

Nasopharyngeal endoscopic images prospectively collected from 8 hospitals all over China

Diagnostic

Intervention Type OTHER

Training dataset was used to train the deep learning model, which was validated and tested by external dataset.

Interventions

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Diagnostic

Training dataset was used to train the deep learning model, which was validated and tested by external dataset.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* The quality of endoscopic images should clinical acceptable.
* Patients were diagnosed with biopsy(NPC, benign hyperplasia). Control corhort(normal nasopharynx) don't require bispsy result.

Exclusion Criteria

* images with spots from lens flares or stains, and overexposure were excluded from further analysis.
* image can not expose most part of lesion clearly.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xiangya Hospital of Central South University

OTHER

Sponsor Role collaborator

The First Affiliated Hospital of Nanchang University

OTHER

Sponsor Role collaborator

Fujian Medical University Union Hospital

OTHER

Sponsor Role collaborator

Quan Zhou First Affiliated Hospital of Fujian Medical University

UNKNOWN

Sponsor Role collaborator

First Affiliated Hospital of Guangxi Medical University

OTHER

Sponsor Role collaborator

People's Hospital of Guangxi Zhuang Autonomous Region

OTHER

Sponsor Role collaborator

The People' s Hospital of Jiangmen

UNKNOWN

Sponsor Role collaborator

Eye & ENT Hospital of Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hongmeng Yu, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Eye&ENT Hospital, Fudan University

Locations

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Fujian Medical University Union Hospital

Fuzhou, Fujian, China

Site Status RECRUITING

Quan Zhou First Affiliated Hospital of Fujian Medical University

Quanzhou, Fujian, China

Site Status RECRUITING

The People' s Hospital of Jiangmen

Jiangmen, Guangdong, China

Site Status RECRUITING

First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

Site Status RECRUITING

The People' s Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi, China

Site Status RECRUITING

Xiangya Hospital of Central South University

Changsha, Hunan, China

Site Status RECRUITING

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Site Status RECRUITING

Eye&ENT Hospital of Fudan University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yu-Xuan Shi, MD PhD

Role: CONTACT

+8618952373378

Facility Contacts

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De-Sheng Wang, MD PhD

Role: primary

Jun Liao, MD PhD

Role: primary

Ming-Zhang Chang, MD

Role: primary

Jie-En Li, MD PhD

Role: primary

Shen-Hong Qu, MD PhD

Role: primary

Wei-Hong Jiang, MD PhD

Role: primary

Jing Ye, MD PhD

Role: primary

Yu-Xuan Shi, MD PhD

Role: primary

Other Identifiers

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AIAD202204

Identifier Type: -

Identifier Source: org_study_id

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