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Prognostic Prediction of NPC Based on MR Diffusion-weighted Imaging

NCT ID: NCT05112510

Last Updated: 2021-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

125 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-01

Study Completion Date

2022-06-01

Brief Summary

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The purpose of this study is to explore whether the imaging model based on RESOLVE-DWI sequence can exploiting the heterogeneity of nasopharyngeal carcinoma and indicate the prognosis, so as to provide intervention information for clinical decision-making. All patients were randomly divided into the training group and the validation group. Radiomics features extracted from T2-weighted, DWI, apparent diffusion coefficient (ADC), and contrast- enhanced T1-weighted were used to build a radiomics model. Patients'clinical variables were also obtained to build a clinical model. Model of training cohort was established using cross-validation for nasopharyngeal carcinoma prognosis by machine learning, including Logistics Regression, SVM, KNN, Decision Tree, Random Forest, XGBoost, and then, the model will be verified in the validation cohort. Area under the curve (AUC) of the Machine learning model was used as the main evaluation metric.

Detailed Description

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Conditions

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Patients With Nasopharyngeal Carcinoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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event group

The patients with nasopharyngeal carcinoma developed distant metastasis or recurrence after standard treatment.

Observing whether developing distant metastasis or recurrence

Intervention Type OTHER

The study is a observational study and has no intervention.

non-event group

The patients with nasopharyngeal carcinoma did not develop distant metastasis or recurrence after standard treatment.

Observing whether developing distant metastasis or recurrence

Intervention Type OTHER

The study is a observational study and has no intervention.

Interventions

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Observing whether developing distant metastasis or recurrence

The study is a observational study and has no intervention.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. patients with nasopharyngeal carcinoma diagnosed by pathology;
2. complete clinical data and MR imaging data;
3. without radiotherapy, chemotherapy or operation before MR examination.

Exclusion Criteria

1. incomplete follow-up data;
2. poor image quality and can not be used for analysis;
3. patients with other tumors in the past or at the same time.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fifth Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The Fifth Affiliated Hospital of Sun Yat-sen University

Zhuhai, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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ZDWY.HYXK.003

Identifier Type: -

Identifier Source: org_study_id