The Effect of Environmental Pollution on the Prognosis of Gastric Cancer

NCT ID: NCT06686966

Last Updated: 2024-11-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 3400 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-01-01
• Study Completion Date: 2024-11-01

Brief Summary

Gastric cancer is one of the common malignant tumours worldwide, with a high incidence especially in East Asia. Although the occurrence of gastric cancer is closely related to genetic factors, lifestyle and dietary habits, in recent years, environmental pollution, especially air pollution, has received more and more attention as a potential carcinogenic factor. Numerous studies have shown that harmful substances in the air such as including passive smoking, soot and oil smoke exposure, incense burning exposure, occupational exposure and outdoor work, PM2.5, PM10, nitrogen oxides, sulphur dioxide, etc. may not only induce the occurrence of gastric cancer, but also affect the prognosis of gastric cancer patients. This experiment intends to determine the extent of the influence of air pollution on the prognosis of gastric cancer by analysing the survival data of gastric cancer patients in areas with different pollution levels. In addition, the association between air pollution levels and postoperative recurrence in gastric cancer patients was investigated to find possible mechanisms.

Conditions

Gastric Cancers

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Interventions

gastric cancer

be diagnosed as gastric cancer

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• patients aged ≥18 years;
• patients diagnosed with gastric cancer by pathological biopsy before surgery;
• patients without chemotherapy, radiotherapy, targeted and immunotherapy before enrolment;
• willing to participate in this study and sign the informed consent;
• complete clinical data.

Exclusion Criteria

• patients with other primary malignant tumours other than gastric cancer;
• patients with systemic diseases such as severe cardiopulmonary insufficiency that affect the choice of treatment plan;
• patients who are not suitable for enrolment as assessed by the investigator;
• incomplete clinical data.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

First Affiliated Hospital of Chongqing Medical University

OTHER

Sponsor Role: lead

Responsible Party

Dong Peng

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

ZZ2024-292-01

Identifier Type: -

Identifier Source: org_study_id