Methods of Post Operative Analgesia in Patients Undergoing Thyroidectomy

NCT ID: NCT07045870

Last Updated: 2025-07-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-11

Study Completion Date

2025-12-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

this study aims to compare between effects of lidocaine and ketamine infusion on postoperative analgesia in patients undergoing thyroidectomy.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Thyroid Disorder

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

group L : will receive lidocaine

lidocaine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

Group Type ACTIVE_COMPARATOR

group L : will receive lidocaine

Intervention Type DRUG

group L : will receive 1.5 mg/kg bolus of iv lidocaine 10 minutes before anaesthesia induction then continuous iv infusion rate 1.5 mg / kg / h

group k : will receive ketamine

Ketamine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

Group Type ACTIVE_COMPARATOR

group k : will receive Ketamine

Intervention Type DRUG

patients will receive .25 mg / kg bolus of iv ketamine 10 minutes before anaesthesia induction then continuous iv infusion of ketamine at .25 mg /kg /h

group c: will receive .9% saline

.9% saline will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

Group Type PLACEBO_COMPARATOR

group c: will recieve .9% saline

Intervention Type DRUG

group c will be injected with equivalent volumes and rates of .9% saline using the same application scheme as the lidocaine and ketamine as a control group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

group L : will receive lidocaine

group L : will receive 1.5 mg/kg bolus of iv lidocaine 10 minutes before anaesthesia induction then continuous iv infusion rate 1.5 mg / kg / h

Intervention Type DRUG

group k : will receive Ketamine

patients will receive .25 mg / kg bolus of iv ketamine 10 minutes before anaesthesia induction then continuous iv infusion of ketamine at .25 mg /kg /h

Intervention Type DRUG

group c: will recieve .9% saline

group c will be injected with equivalent volumes and rates of .9% saline using the same application scheme as the lidocaine and ketamine as a control group

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age from 18 to 75 years old
* both sexes
* scheduled for thyroidectomy

Exclusion Criteria

* toxic goiter
* (BMI) exceeding 30 kg / m2
* un controlled hypertension
* sever liver or kidney disorders
* allergy to study drugs
* hyperthyroidism
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Sohag University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Mario Nashaat

Resident, Anasethesia, Surgical Icu, Pain management Faculty of Medicine, Sohag University

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Sohag university hospital

Sohag, , Egypt

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Mario N Ishak, Resident

Role: CONTACT

01210609798

Abdel Rahman H Abdel Rahman, Professor

Role: CONTACT

01120320258

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Magdy M Amin, Professor

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Ludwig B, Ludwig M, Dziekiewicz A, Mikula A, Cisek J, Biernat S, Kaliszewski K. Modern Surgical Techniques of Thyroidectomy and Advances in the Prevention and Treatment of Perioperative Complications. Cancers (Basel). 2023 May 26;15(11):2931. doi: 10.3390/cancers15112931.

Reference Type BACKGROUND
PMID: 37296896 (View on PubMed)

Javidi S, Sadrizadeh S, Sadrizadeh A, Bonakdaran S, Jarahi L. Postoperative complications and long-term outcomes after total and subtotal thyroidectomy: a retrospective study. Sci Rep. 2025 Jan 29;15(1):3705. doi: 10.1038/s41598-024-79860-8.

Reference Type BACKGROUND
PMID: 39881145 (View on PubMed)

Jain SN, Lamture Y, Krishna M. Enhanced Recovery After Surgery: Exploring the Advances and Strategies. Cureus. 2023 Oct 17;15(10):e47237. doi: 10.7759/cureus.47237. eCollection 2023 Oct.

Reference Type BACKGROUND
PMID: 38022245 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

Soh-Med--25-6-11MS

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Exparel Injection Effect on Postoperative Opioid Usage
NCT04085913 ENROLLING_BY_INVITATION EARLY_PHASE1
Perioperative Lidocaine and Ketamine in Abdominal Surgery
NCT04084548 ACTIVE_NOT_RECRUITING PHASE3