Bilateral Superficial Cervical Block for Thyroidectomy

NCT ID: NCT01171885

Last Updated: 2010-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-31

Study Completion Date

2011-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this study is to compare the postoperative analgesia afforded by bilateral superficial cervical block using different concentrations of local anesthetic (ropivacaine) in patients undergoing total thyroidectomy for the mini-incision technique, performed by the same surgical team.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In this study we will evaluate the efficacy of bilateral superficial cervical block associated with balanced general anesthesia with remifentanil as opioid of choice in preventing postoperative pain in patients who underwent total thyroidectomy with mini incision without neck dissection.A hundred and twenty patients ASA I - II will be assessed and allocated randomly (through a table of random numbers) into three groups for analgesia for post-operative:

Group 1: bilateral superficial cervical block with 20 ml of 0.9% saline (placebo); Group 2: bilateral superficial cervical block with 20 ml ropivacaine 0.25%; Group 3: bilateral superficial cervical block with 20 ml ropivacaine 0.5%.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cervical Pain

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Superficial cervical block Thyroidectomy Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Placebo

Bilateral superficial cervical block.

Group Type PLACEBO_COMPARATOR

0.9% saline

Intervention Type DRUG

20 ml of 0.9% saline

Ropivacaine 0.25%

Bilateral superficial cervical block

Group Type EXPERIMENTAL

Ropivacaine

Intervention Type DRUG

20 ml of Ropivacaine 0.25%.

Ropivacaine 0.5%

Bilateral superficial cervical block.

Group Type EXPERIMENTAL

Ropivacaine

Intervention Type DRUG

20 ml of Ropivacaine 0.5%.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

0.9% saline

20 ml of 0.9% saline

Intervention Type DRUG

Ropivacaine

20 ml of Ropivacaine 0.25%.

Intervention Type DRUG

Ropivacaine

20 ml of Ropivacaine 0.5%.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age greater than 18 years
* Agreed to participate in the study and sign the consent form
* ASA I-II
* Scheduled to undergo total thyroidectomy without neck dissection under general balanced anesthesia.

Exclusion Criteria

* Clinical history or laboratory tests suggestive of bleeding disorder
* Mental or cognitive deficit in existence, which makes it impossible to understand the patient visual analog scale of pain or the study protocol
* Body mass index greater than 45
* History of allergy to local anesthetics
* Intolerance or contraindication to any medication used in the study
* Skin infection at the site of the blockade
* Patients requiring neck dissection
* Pregnancy
* Preoperative use of opioid analgesics or non-opioids, corticosteroids or anti inflammatory non steroidal
* Patient's refusal to participate in the study
* Need for emergency reintervention within the first 24 hours postoperatively
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Federal University of Minas Gerais

OTHER

Sponsor Role collaborator

Lifecenter Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Lifecenter Hospital

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Carlos Leonardo A Boni, MD

Role: PRINCIPAL_INVESTIGATOR

Federal University of Minas Gerais

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Lifecenter Hospital

Belo Horizonte, Minas Gerais, Brazil

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Brazil

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Carlos Leonardo A Boni, MD

Role: CONTACT

Phone: 00553191851959

Email: [email protected]

Yerkes P Silva, PhD

Role: CONTACT

Phone: 00553199933384

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Carlos leonardo A Boni, MD

Role: primary

Yerkes P Silva, PhD

Role: backup

References

Explore related publications, articles, or registry entries linked to this study.

Andrieu G, Amrouni H, Robin E, Carnaille B, Wattier JM, Pattou F, Vallet B, Lebuffe G. Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia. Br J Anaesth. 2007 Oct;99(4):561-6. doi: 10.1093/bja/aem230. Epub 2007 Aug 6.

Reference Type BACKGROUND
PMID: 17681971 (View on PubMed)

Herbland A, Cantini O, Reynier P, Valat P, Jougon J, Arimone Y, Janvier G. The bilateral superficial cervical plexus block with 0.75% ropivacaine administered before or after surgery does not prevent postoperative pain after total thyroidectomy. Reg Anesth Pain Med. 2006 Jan-Feb;31(1):34-9. doi: 10.1016/j.rapm.2005.10.008.

Reference Type BACKGROUND
PMID: 16418022 (View on PubMed)

Eti Z, Irmak P, Gulluoglu BM, Manukyan MN, Gogus FY. Does bilateral superficial cervical plexus block decrease analgesic requirement after thyroid surgery? Anesth Analg. 2006 Apr;102(4):1174-6. doi: 10.1213/01.ane.0000202383.51830.c4.

Reference Type BACKGROUND
PMID: 16551919 (View on PubMed)

Steffen T, Warschkow R, Brandle M, Tarantino I, Clerici T. Randomized controlled trial of bilateral superficial cervical plexus block versus placebo in thyroid surgery. Br J Surg. 2010 Jul;97(7):1000-6. doi: 10.1002/bjs.7077.

Reference Type BACKGROUND
PMID: 20632263 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CAAE-0003.0.419.419-0

Identifier Type: -

Identifier Source: org_study_id