Food and Fitness With Medicine (FFWM)

NCT ID: NCT07027995

Last Updated: 2026-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2029-03-31

Brief Summary

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Food and Fitness with Medicine (FFWM) is a 24-week randomized controlled trial (RCT) enrolling 200 post-menopausal women (PMW) with stage 2 cardio-kidney metabolic (CKM) syndrome and type-2 diabetes (T2D) within 6 weeks of initiating glucagon-like peptide-1 receptor agonist (GLP-1RAs) to: 1. Examine discontinuation rates of GLP-1RAs (primary outcome); 2. Compare change in American Heart Association (AHA) PREVENT scores (secondary outcome); and 3. Examine the effects of FFWM on biologic mechanisms responsive to weight loss and cardiovascular health (CVH) including dermal carotenoids, body composition and metabolite biomarkers.

Detailed Description

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Conditions

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Cardiovascular Kidney Metabolic Syndrome Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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FFWM+

Intervention Group receives medically tailored groceries and culinary training, fitness education and training, behavioral reinforcers, and access to a secure web portal.

Group Type EXPERIMENTAL

Exercise is Medicine (EIM)

Intervention Type BEHAVIORAL

During Phase 1 (Weeks 1-12), participants are enrolled in a comprehensive 12-week fitness education and training program.

Culinary Education

Intervention Type BEHAVIORAL

During Phase 1 \& 2, participants receive monthly hybrid cooking demonstrations with culinary training.

Food is Medicine

Intervention Type BEHAVIORAL

During Phase 1 (Weeks 1-12), participants receive bi-weekly medically tailored grocery vouchers.

Nutrition Counseling

Intervention Type BEHAVIORAL

During Phase 1 (Weeks 1-12), participants engage in weekly behavioral nutrition counseling.

Participant Website

Intervention Type BEHAVIORAL

During Phases 1 and 2, participants will receive digital behavioral reinforcers and access to a secure web portal that provides evidence-based resources.

Standard Care

Control Group - access to optional cooking demos

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise is Medicine (EIM)

During Phase 1 (Weeks 1-12), participants are enrolled in a comprehensive 12-week fitness education and training program.

Intervention Type BEHAVIORAL

Culinary Education

During Phase 1 \& 2, participants receive monthly hybrid cooking demonstrations with culinary training.

Intervention Type BEHAVIORAL

Food is Medicine

During Phase 1 (Weeks 1-12), participants receive bi-weekly medically tailored grocery vouchers.

Intervention Type BEHAVIORAL

Nutrition Counseling

During Phase 1 (Weeks 1-12), participants engage in weekly behavioral nutrition counseling.

Intervention Type BEHAVIORAL

Participant Website

During Phases 1 and 2, participants will receive digital behavioral reinforcers and access to a secure web portal that provides evidence-based resources.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of at least one of the following conditions: hypertension, type 2 diabetes, hyperlipidemia, chronic kidney disease, and/or metabolic syndrome.
* At least 18 years of age at the time of signing consent.
* Participants must have reliable transportation to attend Exercise is Medicine sessions.
* Access to an internet-enabled device.
* No objections to online grocery shopping, home food deliveries, or nutrition counseling.
* Residence meets Instacart delivery requirements (e.g., non-institutionalized).
* Participant is willing to use a personal credit card for Instacart back-up payments.
* Participants must speak English to be able to consent and engage in FIM and EIM programs.
* Participant has been clinically prescribed GLP-1RA's.

Exclusion Criteria

* Conditions that impact digestion, metabolism, or food intake (e.g. surgical loss of esophagus, stomach, or colon, pancreatic dysfunction, bariatric surgery, brain surgery that alters cognition, etc.).
* Participants with uncontrolled mental illness disorders (e.g., schizophrenia, bipolar disorder, major depression, etc.) that are not well-managed or controlled through treatment, as determined by the study team.
* Familial history of certain cancers (e.g., multiple endocrine neoplasia, medullary thyroid carcinoma, etc.).
* Active digestive illnesses (i.e., Celiac disease, irritable bowel syndrome, chronic malabsorption).
* Comorbidities such as psychiatric or general illness that may put the subject at risk as determined by the investigator/s.
* Renal impairment, eGFR \< 60 ml/min/1.73m2
* Factor which, in the investigator's opinion, is likely to compromise the subject's ability to participate in the study.
* Recent participation (e.g., 3 months) in other behavioral nutrition trials or programs (i.e., bariatric programs, diabetes education programs).
* Currently pregnant or planning to become pregnant during the study.
* Participant is not willing to provide a urine, blood, or stool sample.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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American Heart Association

OTHER

Sponsor Role collaborator

Ohio State University

OTHER

Sponsor Role lead

Responsible Party

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Colleen Spees

Professor of Medical Dietetics and Director of Hope Lab

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Colleen K Spees, PhD, MEd, RD

Role: PRINCIPAL_INVESTIGATOR

Ohio State University

Locations

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Ohio State Healthy Community Center

Columbus, Ohio, United States

Site Status ACTIVE_NOT_RECRUITING

Ohio State East Hospital

Columbus, Ohio, United States

Site Status NOT_YET_RECRUITING

Martha Morehouse

Columbus, Ohio, United States

Site Status RECRUITING

Ohio State Outpatient Care Upper Arlington

Upper Arlington, Ohio, United States

Site Status ACTIVE_NOT_RECRUITING

Countries

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United States

Central Contacts

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Jenna N Hauben, BS

Role: CONTACT

9083344689

Cara L Chase, BS

Role: CONTACT

5032789721

Facility Contacts

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Luiza Reopell, MBA

Role: primary

614-572-9191

Jenna Hauben

Role: primary

908-334-4689

Other Identifiers

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STUDY20250193

Identifier Type: -

Identifier Source: org_study_id

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