Hypoxia Adaptation Promotes Cerebral Functional Connectivity With Neuromuscular Efficiency Decrement

NCT ID: NCT07018817

Last Updated: 2025-06-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-07-15
• Study Completion Date: 2024-12-15

Brief Summary

The study utilized a trimodal setup comprising EEG, EMG, and fNIRS modules. Participants wore a 64-channel dry EEG cap, while EMG electrodes were placed on the right biceps brachii, the flexor digitorum profundus of the forearm, and the gastrocnemius muscle. fNIRS probes were positioned on the forehead to monitor cerebral hemodynamic responses.

The experimental paradigm included two tasks: motor execution (ME) and motor imagery (MI). During ME, participants performed 15 trials of actual movements. In MI, participants completed 60 trials of imagined movements. Each trial involved a randomly presented stimulus-left-hand clenching, right-hand clenching, or bilateral heel raising-with each movement type occurring an equal number of times across the session.

Detailed Description

This study employed a multimodal acquisition system comprising EEG, EMG, and fNIRS modules. Participants were fitted with a 64-channel dry EEG cap for the measurement of cortical electrical activity. Surface EMG electrodes were attached to three muscle groups: the right biceps brachii, the flexor digitorum profundus of the forearm, and the gastrocnemius muscle, to record muscle activation signals. Simultaneously, fNIRS probes were positioned on the participants' foreheads to monitor cerebral hemodynamic responses.

The experimental paradigm was divided into two tasks: motor execution (ME) and motor imagery (MI). During the ME task, participants performed 15 trials of actual movements, whereas the MI task involved 60 trials of imagined movements. Each trial randomly presented one of three stimuli-left-hand clenching, right-hand clenching, or bilateral heel raising-with an equal distribution of the three movement types across the session. The order of stimuli was randomized to prevent prediction bias.

Conditions

Hypoxia; Altitude Sickness

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Interventions

motor execution motor imagery

Participants will perform motor execution tasks and motor imagery tasks following standardized instructions under controlled conditions.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• People who can withstand altitude sickness

Exclusion Criteria

• Plateau Native

• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Peking Union Medical College

OTHER

Sponsor Role: lead

Responsible Party

T.Li

Full professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Institute of Biomedical engineering，Chinese Academy of Medical Sciences & Peking Union Medical College

Tianjin, Tianjin Municipality, China

Countries

China

Related Links

https://www.nature.com/articles/s41597-024-03200-8#citeas

Related Info

Other Identifiers

Brain Adaptation to Hypoxia

Identifier Type: -

Identifier Source: org_study_id