The Measurement of Nocturnal Hypokinesia in Parkinson's Disease (PD) Patient Compared With Spouse by Wearable Sensors

NCT ID: NCT02352727

Last Updated: 2015-02-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-31

Brief Summary

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To quantitative measurement of nocturnal hypokinesia of Parkinson's disease patients compares with their spouses by using multisite accelerometers for 1 night at their home. To determine whether the nocturnal movement of Parkinson's disease patients less than normal elderly people or not.

Detailed Description

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To quantify the severity of nocturnal akinesia, the nocturnal akinesia dystonia and cramp score (NADCS) and Unified Parkinson's Disease Rating Scale (UPDRS) were recorded in the patient group and also details of demographic data, history and physical examinations were included. The patients and spouses wore the 3-axis (x,y,z) accelerometers at bilateral wrists, bilateral ankles, and trunk for 1 night at their home. The 5-minute periods after going to bed and before waking up in the morning were excluded from the analysis. The definition of movement of the trunk is a change of 15 degrees from the previous position and sustained for 5 minutes in any axis. The movement of limbs is defined as a change of 15 degrees from the previous position and sustained for 2 minutes.

Conditions

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Parkinson Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Parkinson's disease patients who met the criteria diagnosis of United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) with their spouses which age difference less than 10 years.

Exclusion Criteria

* 1\) patients and/or spouses who were bed ridden,
* 2\) a history of other neurological diseases or other muscle and joint diseases,
* 3\) no history of hypnotic drug use
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Jirada Sringean

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Medicine

Bangkok, Bangkok, Thailand

Site Status

Countries

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Thailand

References

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Stack EL, Ashburn AM. Impaired bed mobility and disordered sleep in Parkinson's disease. Mov Disord. 2006 Sep;21(9):1340-2. doi: 10.1002/mds.20944.

Reference Type BACKGROUND
PMID: 16773640 (View on PubMed)

Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 2009 May;8(5):464-74. doi: 10.1016/S1474-4422(09)70068-7.

Reference Type BACKGROUND
PMID: 19375664 (View on PubMed)

Verbaan D, van Rooden SM, Visser M, Marinus J, van Hilten JJ. Nighttime sleep problems and daytime sleepiness in Parkinson's disease. Mov Disord. 2008 Jan;23(1):35-41. doi: 10.1002/mds.21727.

Reference Type BACKGROUND
PMID: 17960797 (View on PubMed)

Steiger MJ, Thompson PD, Marsden CD. Disordered axial movement in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1996 Dec;61(6):645-8. doi: 10.1136/jnnp.61.6.645.

Reference Type BACKGROUND
PMID: 8971118 (View on PubMed)

Bhidayasiri R, Mekawichai P, Jitkritsadakul O, Panyakaew P, Kaewwilai L, Boonrod N, Petchrutchatachart S, Jagota P, Boonpeng K, Singmaneesakulchai S, Setthawatcharawanich S. Nocturnal journey of body and mind in Parkinson's disease: the manifestations, risk factors and their relationship to daytime symptoms. Evidence from the NIGHT-PD study. J Neural Transm (Vienna). 2014 Aug;121 Suppl 1:S59-68. doi: 10.1007/s00702-014-1199-x. Epub 2014 Mar 31.

Reference Type BACKGROUND
PMID: 24682359 (View on PubMed)

Salarian A, Russmann H, Vingerhoets FJ, Burkhard PR, Aminian K. Ambulatory monitoring of physical activities in patients with Parkinson's disease. IEEE Trans Biomed Eng. 2007 Dec;54(12):2296-9. doi: 10.1109/tbme.2007.896591.

Reference Type BACKGROUND
PMID: 18075046 (View on PubMed)

Yang CC, Hsu YL. A review of accelerometry-based wearable motion detectors for physical activity monitoring. Sensors (Basel). 2010;10(8):7772-88. doi: 10.3390/s100807772. Epub 2010 Aug 20.

Reference Type BACKGROUND
PMID: 22163626 (View on PubMed)

Maetzler W, Domingos J, Srulijes K, Ferreira JJ, Bloem BR. Quantitative wearable sensors for objective assessment of Parkinson's disease. Mov Disord. 2013 Oct;28(12):1628-37. doi: 10.1002/mds.25628. Epub 2013 Sep 12.

Reference Type BACKGROUND
PMID: 24030855 (View on PubMed)

Weller C, Nicholson PW, Dobbs SM, Bowes SG, Purkiss A, Dobbs RJ. Reduced axial rotation in the spouses of sufferers from clinical idiopathic parkinsonism. Age Ageing. 1992 May;21(3):189-94. doi: 10.1093/ageing/21.3.189.

Reference Type RESULT
PMID: 1615781 (View on PubMed)

Weller C, Bowes SG, Kirk CA, Nicholson PW, Dobbs RJ, Dobbs SM. Measurement of axial rotation: its relevance to screening for night-time hypokinesia in old age and parkinsonism. Age Ageing. 1991 Jan;20(1):3-7. doi: 10.1093/ageing/20.1.3.

Reference Type RESULT
PMID: 2028848 (View on PubMed)

Godfrey A, Conway R, Meagher D, OLaighin G. Direct measurement of human movement by accelerometry. Med Eng Phys. 2008 Dec;30(10):1364-86. doi: 10.1016/j.medengphy.2008.09.005. Epub 2008 Nov 8.

Reference Type RESULT
PMID: 18996729 (View on PubMed)

Other Identifiers

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153/57

Identifier Type: -

Identifier Source: org_study_id

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