Amino Acid Metabolism Before and After Bariatric Surgery
NCT ID: NCT07008352
Last Updated: 2025-11-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2025-06-11
2025-11-03
Brief Summary
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Detailed Description
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In this prospective observational study, a total of 100 participants will be enrolled: 50 patients undergoing bariatric surgery and 50 healthy controls. Serum samples will be collected from the patient group preoperatively, and at 1 and 3 months after surgery. The control group will provide one-time blood samples.
All serum samples will be centrifuged and stored at -80°C until analysis. Free amino acid profiles will be determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The primary outcome is to assess the change in amino acid concentrations over time in surgical patients, and to compare them with healthy controls. Secondary analyses will explore correlations between amino acid levels and body mass index (BMI). Data analysis will be performed using SPSS and MetaboAnalyst 5.0.
This study will help clarify how bariatric surgery influences amino acid metabolism and may offer insights into the metabolic mechanisms underlying postoperative recovery and weight regulation.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group 1: Bariatric surgery patients (n=50)
Participants in this group are adults (≥18 years old) with obesity who are scheduled to undergo bariatric surgery at Harran University Hospital. Blood samples will be collected at three time points: before surgery (baseline), and at 1 and 3 months postoperatively. Serum will be separated and stored at -80°C for subsequent amino acid profiling using LC-MS/MS.
Blood sample collection for amino acid profiling
Blood samples (5 mL) will be collected from participants in both groups. In the bariatric surgery group, samples will be collected at three time points: preoperatively, and at 1 and 3 months postoperatively. For the control group, a single sample will be obtained. Serum will be separated, stored at -80°C, and analyzed for free amino acid profiles using LC-MS/MS.
Group 2: Healthy control participants (n=50)
Participants in this group are healthy adults (≥18 years old) with no known history of obesity or chronic metabolic disease. A single blood sample will be collected at baseline. Serum samples will be analyzed using LC-MS/MS to determine amino acid profiles, which will be compared to those of the bariatric surgery group.
Blood sample collection for amino acid profiling
Blood samples (5 mL) will be collected from participants in both groups. In the bariatric surgery group, samples will be collected at three time points: preoperatively, and at 1 and 3 months postoperatively. For the control group, a single sample will be obtained. Serum will be separated, stored at -80°C, and analyzed for free amino acid profiles using LC-MS/MS.
Interventions
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Blood sample collection for amino acid profiling
Blood samples (5 mL) will be collected from participants in both groups. In the bariatric surgery group, samples will be collected at three time points: preoperatively, and at 1 and 3 months postoperatively. For the control group, a single sample will be obtained. Serum will be separated, stored at -80°C, and analyzed for free amino acid profiles using LC-MS/MS.
Eligibility Criteria
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Inclusion Criteria
* Diagnosed with obesity and scheduled for bariatric surgery (study group)
* Healthy individuals with normal BMI (control group)
Exclusion Criteria
* History of metabolic or chronic systemic disease
* Pregnancy or lactation
18 Years
65 Years
ALL
Yes
Sponsors
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Harran University
OTHER
Responsible Party
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Faik TATLI
Professor Dr
Locations
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Veli Fahri Pehlivan
Sanliurfa, , Turkey (Türkiye)
Countries
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Other Identifiers
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Gerger
Identifier Type: -
Identifier Source: org_study_id
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