Preventing Muscle Loss After Bariatric Surgery: Protein-Collagen Supplementation and Resistance Exercise
NCT ID: NCT07303543
Last Updated: 2025-12-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
35 participants
INTERVENTIONAL
2022-08-02
2026-01-30
Brief Summary
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Does whey protein supplementation with collagen combined with resistance exercise prevent muscle mass loss after bariatric surgery? Do whey protein supplementation with collagen combined with resistance exercise affect fat mass after bariatric surgery?
Researchers will compare collagen with whey protein.
The study groups and interventions to be implemented are summarized below:
Group 1: Control Group (CG; n: 10) Whey protein supplementation will be administered Vitamin and mineral supplementation will be administered No resistance exercise will be performed The participants will eat according to bariatric surgery nutrition guidelines and perform physical activities.
Group 2: Whey Protein + Collagen + Exercise Group (WPCEG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.
They will begin a resistance exercise program 4 weeks after surgery.
Group 3: Whey Protein + Collagen + No Exercise Group (WPCG; n: 10) Whey protein supplements with collagen will be given. Vitamin and mineral supplements will be given. No resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.
Group 4: Whey Protein + Exercise Group (WPEG; n: 10) Whey protein supplements will be given. Vitamin and mineral supplements will be given. Resistance exercise will be performed. They will eat according to bariatric surgery nutrition guidelines and perform physical activities.
A resistance exercise program will begin at 4 weeks post-operatively.
Detailed Description
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The use of whey protein to support muscle protein synthesis in the postoperative period is a common practice. In recent years, there has been increased scientific interest in the potential of collagen peptides, especially when used in conjunction with resistance exercise, to contribute to muscle mass preservation. However, studies evaluating the combined effect of collagen supplementation and exercise programs in addition to whey protein in individuals undergoing bariatric surgery are limited.
This clinical study aims to investigate the effectiveness of adding collagen to standard whey protein supplementation and a resistance exercise program in preventing muscle loss. Four different groups will be designed to evaluate the independent and combined effects of collagen and exercise:
1. Group receiving only whey protein,
2. Whey + collagen + exercise group,
3. Whey + collagen but no exercise group,
4. Whey + exercise but no collagen group.
All participants will follow a standard post-bariatric surgery nutrition protocol and receive routine vitamin and mineral supplements. The resistance exercise program will begin four weeks after surgery; it will consist of progressively more intense, supervised exercises targeting large muscle groups. Body composition assessments will be performed at baseline and at specified follow-up weeks. The primary outcome measure is change in skeletal muscle mass; secondary outcome measures are fat mass, functional capacity, and exercise compliance.
This study is expected to contribute to the identification of optimal nutrition and exercise strategies to reduce muscle loss after bariatric surgery.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Control Group (CG)
Whey protein supplementation will be provided. Vitamin and mineral supplementation will be administered. No resistance exercise will be performed. Participants will follow bariatric surgery nutrition guidelines and maintain their regular physical activities.
A comparison will be made with the other groups as the control group.
Whey protein supplement
Oral whey protein supplement provided daily according to bariatric surgery nutrition protocol.
Vitamin and Mineral Supplementation
Routine vitamin and mineral supplementation according to bariatric surgery follow-up protocol.
Whey Protein + Collagen + Exercise Group (WPCEG)
Collagen-containing whey protein supplementation will be provided. Vitamin and mineral supplementation will be given. Resistance exercises will be performed. Participants will follow bariatric surgery nutrition guidelines and maintain their physical activities.
They will begin the resistance exercise program in the 4th week after surgery.
Whey protein supplement
Oral whey protein supplement provided daily according to bariatric surgery nutrition protocol.
Hydrolyzed Collagen Supplement
Oral hydrolyzed collagen supplement provided daily in combination with whey protein.
Vitamin and Mineral Supplementation
Routine vitamin and mineral supplementation according to bariatric surgery follow-up protocol.
Resistance Exercise Program
Structured resistance exercise program initiated at postoperative week 4, supervised, 3 times per week.
Whey Protein + Collagen + Non-Exercise Group (WPCG)
Collagen-containing whey protein supplementation will be provided. Vitamin and mineral supplementation will be administered. No resistance exercises will be performed. Participants will follow bariatric surgery nutrition guidelines and maintain their physical activities.
Whey protein supplement
Oral whey protein supplement provided daily according to bariatric surgery nutrition protocol.
Vitamin and Mineral Supplementation
Routine vitamin and mineral supplementation according to bariatric surgery follow-up protocol.
Whey Protein + Exercise Group (WPEG)
Whey protein supplementation will be provided. Vitamin and mineral supplementation will be given. Resistance exercises will be performed. Participants will follow bariatric surgery nutrition guidelines and maintain their physical activities.
They will begin the resistance exercise program in the 4th week after surgery.
Whey protein supplement
Oral whey protein supplement provided daily according to bariatric surgery nutrition protocol.
Vitamin and Mineral Supplementation
Routine vitamin and mineral supplementation according to bariatric surgery follow-up protocol.
Resistance Exercise Program
Structured resistance exercise program initiated at postoperative week 4, supervised, 3 times per week.
Interventions
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Whey protein supplement
Oral whey protein supplement provided daily according to bariatric surgery nutrition protocol.
Hydrolyzed Collagen Supplement
Oral hydrolyzed collagen supplement provided daily in combination with whey protein.
Vitamin and Mineral Supplementation
Routine vitamin and mineral supplementation according to bariatric surgery follow-up protocol.
Resistance Exercise Program
Structured resistance exercise program initiated at postoperative week 4, supervised, 3 times per week.
Eligibility Criteria
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Inclusion Criteria
* Body mass index; 35 ≤ BMI\< 60 kg/m2
* Not being pregnant
* Not being addicted to alcohol and drugs
* Not having entered menopause
* No exercise restrictions
Exclusion Criteria
* using statins
* be pregnant
* Being addicted to alcohol and drugs
* to have entered menopause
* Having exercise restrictions
* Becoming a professional athlete
* Having done more than 60 minutes of regular and structured exercise per week in the last year
20 Years
50 Years
ALL
No
Sponsors
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Medipol University
OTHER
Responsible Party
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Rüken Aslınur Samanci
Lecturer
Principal Investigators
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Halit E Taşkın, Dr.
Role: PRINCIPAL_INVESTIGATOR
Cerrahpaşa Faculty of Medicine, General Surgery
Nihal Z Erdem, PhD
Role: PRINCIPAL_INVESTIGATOR
Istanbul Medipol University, Nutrition and Dietetics
Bürke Köksalan, PhD
Role: PRINCIPAL_INVESTIGATOR
Locations
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Istanbul Medipol University
Istanbul, Fatih, Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Rüken A Samancı, Msc
Role: primary
Other Identifiers
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E-66291034-772.02-3053
Identifier Type: -
Identifier Source: org_study_id