Silent Threat: Impact of Preoperative Albumin Levels on Outcomes in Geriatric Cancer Surgery

NCT ID: NCT06998030

Last Updated: 2025-06-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

330 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-04-01

Study Completion Date

2025-05-10

Brief Summary

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This retrospective, single-center study aims to evaluate the impact of preoperative albumin levels on postoperative outcomes in geriatric patients (aged 65 and above) undergoing cancer surgery. The study will compare postoperative complication rates, length of hospital stay, and intensive care needs between patients with hypoalbuminemia and those with normal albumin levels.

Detailed Description

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Malnutrition is a significant risk factor for postoperative complications in elderly cancer patients. Preoperative serum albumin is a key biomarker reflecting nutritional and inflammatory status. This study will retrospectively review the medical records of 330 geriatric patients (≥65 years) who underwent cancer surgery at Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital. Patients will be grouped according to preoperative albumin levels: Group 1 (\<3.5 g/dL, hypoalbuminemia) and Group 2 (≥3.5 g/dL, normal). The primary aim is to compare postoperative complication rates, length of hospital stay, and intensive care requirements between these groups. The findings are expected to clarify the prognostic value of albumin and support individualized perioperative management in geriatric cancer surgery.

Conditions

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Neoplasms Aged Hypoalbuminemia Postoperative Complications Malnutrition

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Group 1 (<3.5 g/dL, hypoalbuminemia)

Participants with preoperative serum albumin levels less than 3.5 g/dL. This group represents geriatric cancer surgery patients who are considered to have hypoalbuminemia, indicating poor nutritional and/or inflammatory status prior to surgery.

No interventions assigned to this group

Group 2 (≥3.5 g/dL, normal)

Participants with preoperative serum albumin levels equal to or greater than 3.5 g/dL. This group represents geriatric cancer surgery patients with normal preoperative albumin levels, reflecting adequate nutritional and inflammatory status prior to surgery.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age 65 years or older
* Diagnosed with cancer and underwent cancer surgery
* Preoperative albumin level recorded before surgery

Exclusion Criteria

* Preoperative sepsis, severe infection, or active inflammatory disease
* Emergency or palliative surgery
* Missing preoperative albumin value
* Incomplete medical records or follow-up data
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Mustafa Kemal ŞAHİN

M.D

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mustafa Kemal SAHIN

Role: PRINCIPAL_INVESTIGATOR

MUSTAFA KEMAL SAHİN

Locations

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Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Reanimation

Ankara, Yenimahalle, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Song S, Qiu P, Wang H, Zhang D, Qi Q, Feng L. Low preoperative serum prealbumin levels and risk of postoperative complications after transsphenoidal surgery in nonfunctioning pituitary adenoma. Neurosurg Focus. 2022 Dec;53(6):E6. doi: 10.3171/2022.9.FOCUS22211.

Reference Type BACKGROUND
PMID: 36455266 (View on PubMed)

Caras RJ, Lustik MB, Kern SQ, McMann LP, Sterbis JR. Preoperative Albumin Is Predictive of Early Postoperative Morbidity and Mortality in Common Urologic Oncologic Surgeries. Clin Genitourin Cancer. 2017 Apr;15(2):e255-e262. doi: 10.1016/j.clgc.2016.09.008. Epub 2016 Sep 23.

Reference Type BACKGROUND
PMID: 27765612 (View on PubMed)

Loftus TJ, Brown MP, Slish JH, Rosenthal MD. Serum Levels of Prealbumin and Albumin for Preoperative Risk Stratification. Nutr Clin Pract. 2019 Jun;34(3):340-348. doi: 10.1002/ncp.10271. Epub 2019 Mar 25.

Reference Type BACKGROUND
PMID: 30908744 (View on PubMed)

Heise D, Bednarsch J, Kroh A, Schipper S, Eickhoff R, Lang S, Neumann U, Ulmer F. Operative Time, Age, and Serum Albumin Predict Surgical Morbidity After Laparoscopic Liver Surgery. Surg Innov. 2021 Dec;28(6):714-722. doi: 10.1177/1553350621991223. Epub 2021 Feb 10.

Reference Type BACKGROUND
PMID: 33568020 (View on PubMed)

Other Identifiers

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2025-03/53

Identifier Type: -

Identifier Source: org_study_id

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