Pioglitazone and Empagliflozin for Fatty Liver Disease in Type 2 Diabetes

NCT ID: NCT06989723

Last Updated: 2025-05-25

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE4
• Total Enrollment: 120 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-01-01
• Study Completion Date: 2027-06-30

Brief Summary

This exploratory study will assess the efficacy of combined pioglitazone and empagliflozin therapy in improving hepatic and metabolic outcomes in patients with type 2 diabetes mellitus and metabolic dysfunction-associated fatty liver disease (MAFLD). Although each agent has shown beneficial effects individually, evidence on their combined impact on liver health is scarce. This study seeks to determine whether the combination therapy yields additive improvements in hepatic steatosis, inflammation, and fibrosis, potentially offering a new therapeutic strategy for diabetic patients with fatty liver disease.

Conditions

Type 2 Diabetes; Fatty Liver

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Pioglitazone

Pioglitazone 15mg

Group Type: EXPERIMENTAL

Empagliflozin 10 MG [Jardiance]

Intervention Type: DRUG

Participants will receive empagliflozin 10 mg, administered orally once daily. The tablet may be taken with or without food.

Empagliflozin

Empagliflozin 10mg

Group Type: EXPERIMENTAL

Pioglitazone 15 MG [Actos]

Intervention Type: DRUG

Participants will receive pioglitazone 15 mg, administered orally once daily. The tablet may be taken with or without food.

Pioglitazone & Empagliflozin

Pioglitazone 15mg + Empagliflozin 10mg

Group Type: EXPERIMENTAL

Empagliflozin 10 MG [Jardiance] + Pioglitazone 15 MG [Actos]

Intervention Type: DRUG

Participants will receive one tablet of pioglitazone 15 mg and one tablet of empagliflozin 10 mg, administered orally once daily. Both tablets may be taken with or without food.

Interventions

Pioglitazone 15 MG [Actos]

Participants will receive pioglitazone 15 mg, administered orally once daily. The tablet may be taken with or without food.

Intervention Type: DRUG

Empagliflozin 10 MG [Jardiance]

Participants will receive empagliflozin 10 mg, administered orally once daily. The tablet may be taken with or without food.

Intervention Type: DRUG

Empagliflozin 10 MG [Jardiance] + Pioglitazone 15 MG [Actos]

Participants will receive one tablet of pioglitazone 15 mg and one tablet of empagliflozin 10 mg, administered orally once daily. Both tablets may be taken with or without food.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Adults aged 20 years or older.

2. Patients with inadequately controlled type 2 diabetes mellitus, defined as HbA1c between 7% and 10%, who are currently treated with either:

• Combination therapy of metformin and a sulfonylurea, or
• Combination therapy of metformin and a DPP-4 inhibitor, or
• Metformin monotherapy, or
• Triple therapy (including metformin) provided that sulfonylurea will be discontinued upon study enrollment.

3. Evidence of hepatic steatosis within the past 3 months, confirmed by Fibroscan with a controlled attenuation parameter (CAP) ≥ 268 dB/m (consistent with S2 or greater [≥10% hepatocyte steatosis] according to the 2024 EASL-EASD-EASO guidelines).

4. Presence of at least one of the following metabolic abnormalities:

• Waist circumference ≥90 cm for men or ≥85 cm for women.
• Blood pressure ≥130 mmHg systolic or ≥85 mmHg diastolic, or use of antihypertensive medication.
• Serum triglycerides ≥150 mg/dL or current use of lipid-lowering agents.
• HDL-cholesterol ≤45 mg/dL for men or ≤50 mg/dL for women.
• HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) ≥2.5.
• Serum C-reactive protein (CRP) ≥2 mg/L.

5. No changes in anti-diabetic or metabolic medications within the past 3 months, unless the changes are deemed by the investigator not to affect study outcomes.

Exclusion Criteria

1. Patients receiving insulin therapy or diagnosed with type 1 diabetes mellitus.

2. Use of the following medications within the past 3 months: GLP-1 receptor agonists, SGLT2 inhibitors, rosiglitazone (TZD), vitamin E, or ursodeoxycholic acid (UDCA).

3. Presence of secondary causes of hepatic steatosis unrelated to metabolic dysfunction, such as hepatitis B, hepatitis C, or alcoholic fatty liver disease.

4. Use of medications known to induce hepatic steatosis, including valproic acid, estrogen, tamoxifen, amiodarone, or chloroquine.

5. Severe organ failure, defined as:

• Liver failure: AST or ALT > 5 times the upper normal limit (UNL), serum albumin < 3.2 g/dL, platelet count < 60,000/µL, or Child-Pugh-Turcotte stage B or C.
• Renal failure: Serum creatinine ≥ 2.0 mg/dL, estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m² (CKD-EPI formula), or patients with end-stage renal disease or on dialysis.

6. Presence of hepatocellular carcinoma, active malignancy, or metastatic cancer.

7. History of or active bladder cancer.

8. History of heart failure or current diagnosis of heart failure.

9. Presence of terminal illnesses.

10. History of gallstone disease, chronic pancreatitis, or acute pancreatitis.

11. Underweight patients (body mass index [BMI] < 18.5 kg/m²).

12. Pregnant women or women planning to become pregnant.

13. Known hypersensitivity to the active ingredients or excipients of the study medications.

14. History of diabetic ketoacidosis.

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Celltrion

INDUSTRY

Sponsor Role: collaborator

Seoul National University Bundang Hospital

OTHER

Sponsor Role: lead

Responsible Party

Soo Lim

Clinical Professor and Principal Investigator, Division of Endocrinology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Seoul National University Bundang Hospital

Seongnam-si, , South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Soo Lim Dr, MD PhD

Role: CONTACT

limsoo@snu.ac.kr

+82-31-787-7035

Minji Sohn Dr, PhD

Role: CONTACT

rainbowmjs@naver.com

Facility Contacts

Soo Lim Dr

Role: primary

limsoo@snu.ac.kr

+82-31-787-7035

Other Identifiers

B-2407-911-001

Identifier Type: -

Identifier Source: org_study_id