Enhanced White Light Endoscopy Versus Conventional White Light Endoscopy for Colorectal Adenoma Detection: A Randomized Controlled Trial
NCT ID: NCT06979232
Last Updated: 2025-10-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
800 participants
INTERVENTIONAL
2025-09-20
2026-05-31
Brief Summary
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2. Study Comparing Enhanced White Light Endoscopy (E-WLI) versus Conventional White Light Endoscopy (WLI) for Detection Rates of Sessile Serrated Lesions (SSLs), Total Polyp Detection Rate, and Advanced Adenoma Detection Rate;
3. Study on Polyp Characteristics (Size, Location, etc.) Observed Using Conventional White Light Endoscopy (WLI) and Enhanced White Light Endoscopy (E-WLI).
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SCREENING
SINGLE
Study Groups
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E-WLI
Enhanced White Light Imaging
Enhanced White Light Imaging
Use of E-WLI for colon inspection during both insertion and withdrawal phase of colonoscopy
WLI
White Light lmaging
White Light lmaging
Use of WLl for colon inspection during both insertion and withdrawal phase of colonoscopy
Interventions
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Enhanced White Light Imaging
Use of E-WLI for colon inspection during both insertion and withdrawal phase of colonoscopy
White Light lmaging
Use of WLl for colon inspection during both insertion and withdrawal phase of colonoscopy
Eligibility Criteria
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Inclusion Criteria
* 2\. Patients undergoing colonoscopy for colorectal cancer screening, positive fecal immunochemical test (FIT) results, gastrointestinal symptoms, or follow-up examination after colorectal polyp treatment
* 3\. Capable of providing informed consent and agreeing to participate
* 4\. Able and willing to follow all research processes
Exclusion Criteria
* 2\. Participated in clinical trials of drugs and is in the discontinuation period of experimental or control drugs;
* 3\. Have had drug or alcohol abuse or psychological disorders in the past five years.
* 4\. Pregnant or lactating patients;
* 5\. Known to have polyposis syndrome;
* 6\. Patients with gastrointestinal bleeding;
* 7\. Previous history of inflammatory bowel disease, colorectal cancer, or colorectal surgery;
* 8.Patients with contraindications to tissue biopsy;
* 9\. History of allergies to the ingredients in intestinal cleansers;
* 10\. Individuals with conditions such as intestinal obstruction or perforation, toxic megacolon, heart failure (grade III or IV), severe cardiovascular disease, severe liver failure, or renal insufficiency, among others.
* 11\. Researchers believe that patients are not suitable to participate in the trial.
45 Years
85 Years
ALL
No
Sponsors
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Shanghai Jiao Tong University School of Medicine
OTHER
Responsible Party
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Xiaobo Li
Chief physician
Locations
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Chongqing General Hospital
Chongqing, Chongqing Municipality, China
The First People's Hospital of Lanzhou City
Lanzhou, Gansu, China
The Third Affiliated Hospital of Heilongjiang University of Chinese Medicine
Harbin, Heilongjiang, China
Armed Police Forces Hospital of Sichuan
Leshan, Sichuan, China
People's Hospital of Bayingolin Mongol Autonomous Prefecture
Korla, Xinjiang, China
Ningbo Ninth Hospital
Ningbo, Zhejiang, China
Taizhou First People's Hospital
Taizhou, Zhejiang, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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LY2024-320-C
Identifier Type: -
Identifier Source: org_study_id
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