Visual Field Changes and OCT Angiographic Chorioretinal Changes in Patients With Primary Open Angle Glaucoma

NCT ID: NCT06978101

Last Updated: 2025-05-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-12-30
• Study Completion Date: 2023-12-30

Brief Summary

This study aimed to assess the correlation between visual field changes and optical coherence tomography (OCT) angiography changes of retinal nerve fiber layer in patients with primary open angle glaucoma.

Detailed Description

Glaucoma is the leading cause of irreversible blindness worldwide. Since glaucomatous damage is preventable but irreversible, an early diagnosis and close follow-up of glaucoma patients are primordial. Optical coherence tomography angiography (OCTA) is a recently developed, noninvasive imaging modality that detects blood flow through the motion contrast generated by red blood cells.

Currently, there are 2 groups of complementary exams used for the diagnosis and follow-up of glaucoma patients: structural (where OCT has a considerable role) and functional (visual field) optic nerve measurements, Both technologies have strengths and limitations.

A new technology for diagnosis and follow-up that can avoid the limitations summarized above is lacking. OCTA seems to be a good candidate for such a role, OCT can detect the Doppler frequency shift of the backscattered light that provides information on blood flow.

Conditions

Visual Field; OCT Angiography; Chorioretinal Changes; Primary Open Angle Glaucoma

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

POAG group

Patients had intraocular pressure (IOP)\>21 mmHg,

POAG group

Intervention Type: OTHER

Patients had intraocular pressure (IOP)\>21 mmHg.

Control group

Patients without family history of primary open-angle glaucoma (POAG), IOP ˂21mm Hg.

Control group

Intervention Type: OTHER

Patients without family history of primary open-angle glaucoma (POAG), IOP ˂21mm Hg.

Interventions

POAG group

Patients had intraocular pressure (IOP)\>21 mmHg.

Intervention Type: OTHER

Control group

Patients without family history of primary open-angle glaucoma (POAG), IOP ˂21mm Hg.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Primary open angle glaucoma patients.

Exclusion Criteria

1. Hazy media.

2. Diabetic Retinopathy.

3. Uveitis.

4. Other Glaucomas

• Acute congestive glaucoma
• Secondary glaucomas

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Miadaa Hassan Hassaneen

Assistant Lecturer of Ophthalmology Department, Al-Azhar Faculty of Medicine in Assiut.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Assiut university

Asyut, , Egypt

Countries

Egypt

Other Identifiers

MD/AZ.AST./OPH026/10/191/1/202

Identifier Type: -

Identifier Source: org_study_id