Heart Rate Variability as a Predictor of Rebound Pain Following Total Knee Arthroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

110 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-20

Study Completion Date

2025-12-25

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to investigate whether heart rate variability (HRV), a marker of autonomic nervous system activity, can predict the occurrence of rebound pain after total knee arthroplasty (TKA). Rebound pain is defined as a sudden and intense pain episode (NRS ≥7) that typically arises after the resolution of peripheral nerve blocks used for postoperative analgesia.

Patients undergoing elective unilateral TKA under spinal anesthesia with peripheral nerve blocks will be included. HRV will be measured both before and after surgery using a chest-worn heart rate monitor. Pain levels, analgesic consumption, sleep quality, and patient satisfaction will also be recorded. The primary goal is to determine whether perioperative HRV values can serve as a predictive biomarker for rebound pain.

Secondary outcomes include the relationship between HRV and pain intensity, opioid use, sleep quality, and length of hospital stay. The findings may contribute to developing individualized pain management strategies for TKA patients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Preoperative Measurement of Heart Rate Variability as a Predictor of Postoperative Outcome

NCT02375412

Major Abdominal Surgery

COMPLETED

Physiological Data Analysis of Patients Undergoing Anesthesia for Liver Transplantation

NCT03694301

Liver Transplantation

UNKNOWN

Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method

NCT02988219

Arrhythmia, Cardiac Kidney Cancer Surgery +1 more

COMPLETED PHASE4

Effect of Progressive Muscle Relaxation on Fear of Falling, Pain, and Anxiety in Arthroplasty Patients

NCT07098390

Arthoplasty, Pain, Anxiety

RECRUITING NA

Analyzing the Noxious Autonomic Response During Shoulder Arthroscope Surgery

NCT03688529

Monitoring, Physiologic Intraoperative Neurophysiological Monitoring Anesthesia and Analgesia +1 more

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Rebound Pain Total Knee Arthroplasty Postoperative Pain, Chronic Heart Rate Variability

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age between 18 and 70 years
* American Society of Anesthesiologists (ASA) physical status I-III
* Scheduled for elective, unilateral total knee arthroplasty under spinal anesthesia
* Planned use of multimodal analgesia including peripheral nerve blocks
* Ability to provide written informed consent
* Ability to understand and complete pain diaries and questionnaires

Exclusion Criteria

* Known allergy to local anesthetics
* Contraindications to regional anesthesia
* Contraindications to spinal anesthesia
* ASA physical status IV or higher
* Pregnancy or breastfeeding
* Neurological or psychiatric disorders impairing ability to participate or report outcomes
* Use of anticoagulant therapy or presence of coagulation disorders
* Infection at the proposed injection site
* Emergency (non-elective) surgical procedures

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No