Exploring Clinical Characteristics of Liver Disease Patients Based on Digestive Metabolic Exhaled Air
NCT ID: NCT06968234
Last Updated: 2025-05-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1000 participants
OBSERVATIONAL
2025-03-01
2028-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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H₂ abnormality
Fasting end-expiratory H₂ ≥ 10 ppm, indicating excessive growth of hydrogen-producing bacteria in the gut.
No interventions assigned to this group
CH₄ abnormality
Fasting end-expiratory CH₄ ≥ 5 ppm, indicating excessive growth of methanogenic archaea in the gut.
No interventions assigned to this group
H₂S abnormality
Fasting end-expiratory H₂S ≥ 50 ppb, indicating excessive growth of hydrogen sulfide-producing bacteria in the gut.
No interventions assigned to this group
NO abnormality
Fasting end-expiratory NO ≥ 15 ppb, indicating the presence of low-grade intestinal inflammation or eosinophilic inflammation.
No interventions assigned to this group
Small Intestinal Bacterial Overgrowth (SIBO)
Defined as end-expiratory H₂ ≥ 10 ppm or CH₄ ≥ 5 ppm.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
② Undergo molecular breath testing within one week of admission.
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Shanghai Zhongshan Hospital
OTHER
Responsible Party
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Principal Investigators
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Shiyao Chen, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Shanghai Zhongshan Hospital
Locations
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Shanghai Geriatrics Medical Center
Shanghai, Shanghai Municipality, China
Shanghai Minhang District Central Hospital
Shanghai, Shanghai Municipality, China
Zhongshan Hospital
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Role: primary
Other Identifiers
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B2025-179R
Identifier Type: -
Identifier Source: org_study_id
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