Effect of Transjugular Intrahepatic Portosystemic Shunt on Gut Microbiota in Cirrhotic Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-08-31

Study Completion Date

2016-04-30

Brief Summary

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The purpose of this study is to determine the effect of transjugular intrahepatic portosystemic shunt on gut microbiota and associated inflammatory factors in cirrhotic patients.

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Detailed Description

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Cirrhosis is associated with qualitative and quantitative changes in the gut microbiota that can potentiate disease progression and complications such as hepatic encephalopathy (HE) and infections. Dysbiosis or altered gut microbiota, due to decreased autochthonous or commensal taxa, has been found in stool and colonic mucosa in cirrhotic patients, which is in turn linked with disease severity and systemic inflammation.

TIPS can decompress the hypertensive portal vein,so that the intestinal congestion can be decrease too. Hence we summarize that TIPS may have effect on gut microbiota and associated inflammatory factors in cirrhotic patients.

Conditions

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Cirrhosis Acquired Portal-systemic Shunt Due to Cirrhosis Hepatic Encephalopathy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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TIPS group

patients who have transjugular intrahepatic portosystemic shunt

No interventions assigned to this group

Non-TIPS group

patients who have endoscopic variceal ligation

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Cirrhotic patients who received TIPS;
* Treatment-naive to TIPS and major operation involving liver such as surgical shunt, hepatic resection and liver transplantation)

Exclusion Criteria

* Uncontrolled infection or sepsis;
* Hepatobiliary or pancreatic malignancy or biliary obstruction;
* Vital organ dysfunction;
* Administration of antibiotics (after TIPS and 2 weeks before TIPS);
* Cachexia;
* Pregnant or breeding women

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No