Handgrip Strength Increases the Pressure in the Portal and Left Gastric Veins in Cirrhotic Patients
NCT ID: NCT07289698
Last Updated: 2025-12-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
64 participants
OBSERVATIONAL
2025-12-10
2026-02-10
Brief Summary
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3\. Method: observational study. Detection Timing: Doppler ultrasound was employed to determine the portal flow velocity and direction at baseline and during the handgrip strength test in cirrhotic patients with a history of variceal bleeding. Three days later, prior to TIPS placement, the pressures in the portal pressure and gastric vein pressure were measured both before and after handgrip strength. Furthermore, carvedilol and vasoactive drugs were discontinued three days before the study commenced. 4. Elaboration of the Research Hypothesis 4.1. Core Hypothesis The handgrip strength level in patients with liver cirrhosis is correlated with portal venous system hemodynamic indices. Specifically, enhanced handgrip strength may affect portal hypertension and the hemodynamics of varicose veins by improving systemic muscle function or circulatory status. 4.2. Speculation on potential mechanisms Association between muscle function and circulation: As a representative of systemic muscle function, increased handgrip strength may reflect an increase in cardiac output or changes in splanchnic vascular resistance, thereby influencing portal venous hemodynamics.
Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Portal pressure measurement group
Handgrip strength
Jamar Hand Dynamometer, from Illinois, USA. Maximum handgrip strength was measured three times, with each measurement lasting 3 seconds and a 1-minute interval between tests
Doppler Ultrasound Measurement Group
Handgrip strength
Jamar Hand Dynamometer, from Illinois, USA. Maximum handgrip strength was measured three times, with each measurement lasting 3 seconds and a 1-minute interval between tests
Interventions
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Handgrip strength
Jamar Hand Dynamometer, from Illinois, USA. Maximum handgrip strength was measured three times, with each measurement lasting 3 seconds and a 1-minute interval between tests
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Moderate to severe pulmonary hypertension
* Uncontrolled systemic infection
* Lesions (e.g., cysts) or tumors in the liver parenchyma that preclude TIPS creation
* Overt hepatic encephalopathy
* Unrelieved biliary obstruction
* Child-Pugh score \> 13
* Model for end-stage liver disease (MELD) score \> 18
* International normalized ratio (INR) \> 5
* Platelet count \< 20×109/mm3
* Participants who had undergone hand or wrist surgery within the previous 3 months or were unable to hold the dynamometer with the testing hand were excluded from the study.
18 Years
ALL
Yes
Sponsors
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The First Affiliated Hospital of Henan University of Science and Technology
OTHER
Shanxi Provincial People's Hospital
OTHER_GOV
Responsible Party
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Locations
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The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China
Shanxi Provincial People's Hospital
Taiyuan, Shanxi, China
Countries
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Central Contacts
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Facility Contacts
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Yaojian Rao, M.D.
Role: primary
mingyuan Zhao, M.D.
Role: primary
Other Identifiers
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MZ
Identifier Type: -
Identifier Source: org_study_id